Maxwell M H, Martindale L
Res Vet Sci. 1985 Nov;39(3):340-52.
Kidneys from young fowl fed a salt deficient diet for up to five weeks were examined under the electron microscope. The presence of maculae densae (MD) were confirmed and the concentrations of nuclei in the MD and the remainder of the distal convoluted tubules were compared. In the proximal convoluted tubules, salt deprivation caused mitochondrial changes, an increase in intranuclear and cytoplasmic lipid and the deposition of urates. Regional thickening of the glomerular basement membrane was observed in many kidneys. In the normal kidney, there is an age dependent increase in the juxtaglomerular granules in the cortical glomeruli (P less than 0.02), but not in the juxtamedullary glomeruli. In salt deprived birds, juxtaglomerular granules were increased in the juxtamedullary glomeruli (P less than 0.01) but not in the cortical glomeruli. Salt deprivation also caused a significant reduction in bodyweight after five weeks (P less than 0.002) and increases in heterophil (P less than 0.02) and monocyte (P less than 0.05) counts in the blood.
对喂食缺盐饮食长达五周的幼禽肾脏进行了电子显微镜检查。证实了致密斑（MD）的存在，并比较了MD和远曲小管其余部分的细胞核浓度。在近曲小管中，缺盐导致线粒体变化、核内和细胞质脂质增加以及尿酸盐沉积。在许多肾脏中观察到肾小球基底膜的局部增厚。在正常肾脏中，皮质肾小球的球旁颗粒随年龄增加（P<0.02），但髓旁肾小球则不然。在缺盐的鸟类中，髓旁肾小球的球旁颗粒增加（P<0.01），而皮质肾小球则没有。缺盐还导致五周后体重显著减轻（P<0.002），血液中嗜异性粒细胞（P<0.02）和单核细胞（P<0.05）计数增加。
