Meng Yang
Department of Pediatrics, The First People's Hospital of Yancheng, Yancheng, Jiangsu Province, China.
J Med Case Rep. 2025 Aug 15;19(1):406. doi: 10.1186/s13256-025-05485-8.
Langerhans cell histiocytosis is a rare condition characterized by diverse clinical manifestations, ranging from cutaneous lesions to systemic involvement. Although Langerhans cell histiocytosis occurs infrequently in newborns, its diagnosis during this period presents significant challenges.
A 1-day-old Chinese female infant presented with multiple red papules at birth and was diagnosed with Langerhans cell histiocytosis following a second skin biopsy. Despite symptomatic treatment, the child experienced recurrent fever and gastrointestinal bleeding. Tafinlar treatment was initiated at 2 months of age, which improved her symptoms.
Prompt identification of Langerhans cell histiocytosis in newborns remains challenging owing to the disease's complexity and varied clinical manifestations; thus, it is essential to advance pathological technologies for Langerhans cell histiocytosis detection.
朗格汉斯细胞组织细胞增多症是一种罕见疾病，其临床表现多样，从皮肤病变到全身受累不等。尽管朗格汉斯细胞组织细胞增多症在新生儿中很少见，但在此期间进行诊断面临重大挑战。
一名1日龄中国女婴出生时出现多个红色丘疹，第二次皮肤活检后被诊断为朗格汉斯细胞组织细胞增多症。尽管进行了对症治疗，该患儿仍反复发热并出现胃肠道出血。2个月大时开始使用泰菲乐治疗，症状有所改善。
由于该疾病的复杂性和临床表现多样，新生儿朗格汉斯细胞组织细胞增多症的及时诊断仍然具有挑战性；因此，推进朗格汉斯细胞组织细胞增多症检测的病理技术至关重要。
