一种具有强效抗生育作用的组织选择性前列腺素E2类似物。
A tissue-selective prostaglandin E2 analog with potent antifertility effects.
作者信息
Hess H J, Bindra J S, Constantine J W, Elger W, Loge O, Schillinger E, Losert W
出版信息
Experientia. 1977 Aug 15;33(8):1076-7. doi: 10.1007/BF01945979.
PMID:408180
Abstract
N-methanesulfonyl 16-phenoxy-omega-tetranor PGE2 is a prostaglandin analog which is markedly more tissue selective than PGE2. This compound is 10-30 times more potent than PGE2 in animal models which are considered relevant to antifertility effects in humans. In pharmacological tests which are believed to be predictive for side effects in humans, the compound has potency either equal to or less than that of PGE2.
摘要
N-甲磺酰基16-苯氧基-ω-四降前列腺素E2是一种前列腺素类似物，其组织选择性明显高于前列腺素E2。在被认为与人类抗生育作用相关的动物模型中，该化合物的效力比前列腺素E2强10至30倍。在被认为可预测人类副作用的药理试验中，该化合物的效力等于或低于前列腺素E2。
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本文引用的文献
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Endocrine activity of the early placenta of the guinea-pig.豚鼠早期胎盘的内分泌活动。
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Enteropooling assay: a test for diarrhea produced by prostaglandins.肠内积液试验：一种检测前列腺素所致腹泻的试验。
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The current status of prostaglandins as abortifacients.前列腺素作为堕胎药的现状。
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