利用蘑菇酪氨酸酶简便一步合成半胱氨酰多巴胺。
A facile one-step synthesis of cysteinyldopas using mushroom tyrosinase.
作者信息
Ito S, Prota G
出版信息
Experientia. 1977 Aug 15;33(8):1118-9. doi: 10.1007/BF01946005.
PMID:408183
Abstract
A convenient one-step procedure, based upon the tyrosinase co-oxidation of dopa and cysteine, is reported for the synthesis of 5-S-cysteinyldopa (I) in 74% yield. Secondary products of the reaction turned out to be 2-S-cysteinyldopa (II, 14%), 2,5-S, S-dicysteinyldopa (iv, 5%), and the hitherto unknown 6-S-cysteinyldopa (III, approximately 1%).
摘要
报道了一种基于多巴和半胱氨酸的酪氨酸酶共氧化反应的简便一步法，用于合成5-S-半胱氨酰多巴（I），产率为74%。该反应的副产物为2-S-半胱氨酰多巴（II，14%）、2,5-S，S-二半胱氨酰多巴（IV，5%）以及迄今未知的6-S-半胱氨酰多巴（III，约1%）。
Zotero 插件