Al-Hasani Wiaam, Ranasinghe Ruvini, Chin Yip Han, Chew Han Shi Jocelyn, Mazahiri Tina, Herath Nalinda, Lajeunesse-Trempe Fannie, Roser Pia, Grady Starlene, Lee Amy, Altmeyer Randolf, Chew Nicholas W S, Vincent Royce P, El-Hasani Shamsi, Dimitriadis Georgios K
Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Sci Rep. 2025 Aug 17;15(1):30106. doi: 10.1038/s41598-025-12997-2.
One anastomosis gastric bypass (OAGB) is a relatively novel bypass surgery variant, increasingly used as a primary surgical procedure. A total of 101 patients (mean age 44.7 ± 10.7 years, mean BMI 47.2 ± 6.6 kg/m2) underwent OAGB between 2014 and 2019 in a single institution. Results obtained 6,12 and 24 months postoperatively were compared with the pre-operative values using "Analyse-it software v5.40.2" and Graphpad Prism v9.3 for figures and tables. Data were tested for normality, described as Mean ± SD, compared using paired sample t-test with 5% p-value for significance and 95% confidence interval (CI). A significant body mass index (BMI), haemoglobin A1c (HbA1c) and low-density lipoprotein (LDL) reduction was recorded throughout follow-up period, with greatest improvement seen 2 years after surgery (47.6 ± 22 kg/m2 vs. 29.4 ± 6.4 kg/m2 ,6.7 ± 1.8% vs. 5.5 ± 0.2% and 3.2 ± 1 vs. 2.05 + 0.7 mmol/ l, p < 0.05). The number of glucose-lowering drugs decreased from 1.6 ± 0.9 to 0.3 ± 0.4 at 24-months, p < 0.001. The rates for zinc, ferritin, folate, B12 and vitamin D deficiency at 24-months were: 8.9%,4%, 5.9%, 0% and 3% respectively. OAGB can effectively downstage obesity disease and improve glucose and lipid homeostasis with a low risk for nutritional deficiencies. This study is one of few to report specifically on the frequency and type of nutritional deficiencies following OAGB surgery.
单吻合口胃旁路术（OAGB）是一种相对新颖的旁路手术变体，越来越多地被用作主要外科手术。2014年至2019年期间，一家机构共有101例患者（平均年龄44.7±10.7岁，平均体重指数47.2±6.6kg/m²）接受了OAGB手术。术后6个月、12个月和24个月获得的结果与术前值进行比较，使用“Analyse-it软件v5.40.2”和Graphpad Prism v9.3制作图表。对数据进行正态性检验，以均值±标准差描述，使用配对样本t检验进行比较，显著性p值为5%，置信区间（CI）为95%。在整个随访期间，体重指数（BMI）、糖化血红蛋白（HbA1c）和低密度脂蛋白（LDL）均显著降低，术后2年改善最为明显（47.6±22kg/m²对29.4±6.4kg/m²，6.7±1.8%对5.5±0.2%，3.2±1对2.05+0.7mmol/l，p<0.05）。降糖药物数量在24个月时从1.6±0.9降至0.3±0.4，p<0.001。24个月时锌、铁蛋白、叶酸、维生素B12和维生素D缺乏率分别为8.9%、4%、5.9%、0%和3%。OAGB可以有效降低肥胖疾病的严重程度，改善糖脂稳态，且营养缺乏风险较低。本研究是少数专门报道OAGB手术后营养缺乏频率和类型的研究之一。
