Wu Hong, Pu Xiaoping
Department of Otolaryngology, Xishan People's Hospital of Wuxi Wuxi 214100, Jiangsu, China.
Am J Transl Res. 2025 Jul 15;17(7):5152-5162. doi: 10.62347/POVL4849. eCollection 2025.
To evaluate the effects of regular nasal irrigation on nasal microbiota and symptom improvement in allergic rhinitis patients.
This retrospective study involved 202 allergic rhinitis patients. Participants were divided into a conventional treatment group (mometasone furoate spray and loratadine) and an observation group (nasal irrigation added to the conventional regimen). Nasal microbiota diversity, biofilm formation, nasal symptoms, and quality of life were assessed before and after a one month of treatment. A correlation analysis was performed to evaluate the relationships between nasal irrigation and clinical outcomes.
The nasal irrigation group exhibited significant reductions in nasal microbiota richness (P = 0.014), biofilm-forming and (P < 0.001, P = 0.001, respectively), with improvements in nasal pruritus, rhinorrhea, congestion, and sneezing (all P < 0.05), compared to the conventional treatment group. Post-treatment, the nasal irrigation group showed more notable improvement in quality of life scores (P = 0.007). Correlation analysis revealed significant associations between nasal irrigation, reduced microbial richness, and symptom severity.
Regular nasal irrigation serves as an effective adjunctive treatment for allergic rhinitis by modulating nasal microbiota, alleviating symptoms, and enhancing quality of life.
评估定期鼻腔冲洗对过敏性鼻炎患者鼻腔微生物群及症状改善的影响。
这项回顾性研究纳入了202例过敏性鼻炎患者。参与者被分为常规治疗组（糠酸莫米松喷雾剂和氯雷他定）和观察组（在常规治疗方案基础上加用鼻腔冲洗）。在治疗1个月前后评估鼻腔微生物群多样性、生物膜形成、鼻腔症状及生活质量。进行相关性分析以评估鼻腔冲洗与临床结局之间的关系。
与常规治疗组相比，鼻腔冲洗组的鼻腔微生物群丰富度显著降低（P = 0.014），生物膜形成也显著减少（分别为P < 0.001，P = 0.001），同时鼻痒、流涕、鼻塞和打喷嚏症状均有改善（均P < 0.05）。治疗后，鼻腔冲洗组的生活质量评分改善更显著（P = 0.007）。相关性分析显示鼻腔冲洗、微生物丰富度降低与症状严重程度之间存在显著关联。
定期鼻腔冲洗可通过调节鼻腔微生物群、缓解症状和提高生活质量，作为过敏性鼻炎的一种有效辅助治疗方法。
