Hu Yucheng, Zhang Rong, Li Junjie, Wang Huan, Wang Meiya, Ren Qiuyi, Fang Yueqi, Tian Li
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.
J Asthma Allergy. 2024 Jul 9;17:633-651. doi: 10.2147/JAA.S472632. eCollection 2024.
Allergic rhinitis is a chronic non-infectious inflammation of the nasal mucosa mediated by specific IgE. Recently, the human microbiome has drawn broad interest as a potential new target for treating this condition. This paper succinctly summarizes the main findings of 17 eligible studies published by February 2024, involving 1044 allergic rhinitis patients and 954 healthy controls from 5 countries. These studies examine differences in the human microbiome across important mucosal interfaces, including the nasal and intestinal areas, between patients and controls. Overall, findings suggest variations in the gut microbiota between allergic rhinitis patients and healthy individuals, although the specific bacterial taxa that significantly changed were not always consistent across studies. Due to the limited scope of existing research and patient coverage, the relationship between the nasal microbiome and allergic rhinitis remains inconclusive. The article discusses the potential immune-regulating role of the gut microbiome in allergic rhinitis. Further well-designed clinical trials with large-scale recruitment of allergic rhinitis patients are encouraged.
变应性鼻炎是一种由特异性IgE介导的鼻黏膜慢性非感染性炎症。最近，人类微生物群作为治疗这种疾病的潜在新靶点引起了广泛关注。本文简要总结了截至2024年2月发表的17项符合条件的研究的主要结果，这些研究涉及来自5个国家的1044例变应性鼻炎患者和954例健康对照。这些研究考察了患者与对照之间在包括鼻腔和肠道区域在内的重要黏膜界面的人类微生物群差异。总体而言，研究结果表明变应性鼻炎患者与健康个体之间肠道微生物群存在差异，尽管各研究中显著变化的具体细菌分类群并不总是一致的。由于现有研究范围和患者覆盖范围有限，鼻腔微生物群与变应性鼻炎之间的关系仍无定论。本文讨论了肠道微生物群在变应性鼻炎中潜在的免疫调节作用。鼓励开展进一步精心设计的、大规模招募变应性鼻炎患者的临床试验。
