Androgenetic alopecia (AGA) is a prevalent condition that significantly impacts psychological well-being and quality of life. Traditional therapies such as minoxidil and platelet-rich plasma (PRP) offer varying degrees of success, while exosome therapy has recently emerged as a potential alternative. This review compares the effectiveness, safety, and patient-centered outcomes of exosome therapy, PRP, and minoxidil in the management of AGA. The findings suggest that exosome therapy shows the most promising results in terms of hair regrowth and safety, followed by PRP, which offers moderate benefits. Minoxidil remains the most accessible treatment, though with more limited effectiveness and the need for continuous use. Overall, exosome therapy appears to hold the greatest potential for long-term improvement. Further research is needed to guide clinical decision-making and optimize treatment outcomes.