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探索超重和肥胖女性的人体测量学、生物化学和营养特征:塞尔维亚队列研究的见解:一项试点研究。

Exploring anthropometric, biochemistry and nutritional attributes in overweight and obese women: Insights from the Serbian cohort: A pilot study.

作者信息

Petrović Anka, Ivanović Nevena, Milinković Neda, Milenković Danijela, Polovina Snežana, Zeković Milica, Đorđević Brižita

机构信息

University of Belgrade, Faculty of Pharmacy, Department of Bromatology, Belgrade.

University of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade.

出版信息

J Med Biochem. 2025 Jun 13;44(3):637-652. doi: 10.5937/jomb0-52980.

Abstract

BACKGROUND

Anthropometric measurements (AMs), such as waist circumference and body mass index (BMI), are dominant indicators of overweight and obesity. Nevertheless, other AMs, such as waist-hip ratio, waist circumference and indices of visceral adiposity index (VAI), body mass fat index (BMFI), cardiometabolic index (CMI) and waist-to-height ratio (WtHR) are more significant and discriminatory than BMI in predicting cardiometabolic risk.

METHODS

This pilot study aimed to comprehensively investigate the anthropometric, biochemical and nutritional characteristics of a sample of overweight and obese women in Serbia, focusing on potential differences related to AM and its association with specific biochemical markers.

RESULTS

The final analytical sample consisted of 57 females (average age 37.16±7.27 years, range: 21-55 years). A strong positive correlation was observed between triglycerides (TG) and both the VAI (r=0.896, p<0.001) and the CMI (r=0.896, p<0.001), both with high statistical significance. Conversely, a strong negative correlation was found between high-density lipoprotein cholesterol (HDLc) and both VAI (r=-0.601, p<0.001) and CMI (r=-0.566, p<0.001). Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly positively correlated with both WtHR and BMFI: SBP and WtHR (r=0.343, p=0.009), SBP and BMFI (r=0.310, p=0.019), DBP and WtHR (r=0.368, p=0.005), and DBP and BMFI (r=0.377, p=0.004). The analysis of biochemical parameters indicated no significant differences between groups, except for TG levels, which were significantly higher in the obese group (p=0.045).

CONCLUSIONS

Although the AMs of the subjects were significantly different, energy intake and macronutrient intake were not significantly different. We did not find significant differences in the intake of most vitamins or minerals between the groups. Additionally, there is inadequate intake of essential nutrients such as vitamin D, iron and selenium, which are critical for overall health. Both groups did not meet the recommended folate intake, which may increase the risk of fetal neural tube defects.

摘要

背景

人体测量指标(AMs),如腰围和体重指数(BMI),是超重和肥胖的主要指标。然而,其他人体测量指标,如腰臀比、腰围以及内脏脂肪指数(VAI)、身体脂肪质量指数(BMFI)、心脏代谢指数(CMI)和腰高比(WtHR),在预测心脏代谢风险方面比BMI更具显著性和区分性。

方法

这项初步研究旨在全面调查塞尔维亚超重和肥胖女性样本的人体测量、生化和营养特征,重点关注与人体测量指标相关的潜在差异及其与特定生化标志物的关联。

结果

最终分析样本包括57名女性(平均年龄37.16±7.27岁,范围:21 - 55岁)。甘油三酯(TG)与VAI(r = 0.896,p < 0.001)和CMI(r = 0.896,p < 0.001)之间均观察到强正相关,且均具有高度统计学意义。相反,高密度脂蛋白胆固醇(HDLc)与VAI(r = -0.601,p < 0.001)和CMI(r = -0.566,p < 0.001)之间均发现强负相关。收缩压(SBP)和舒张压(DBP)与WtHR和BMFI均显著正相关:SBP与WtHR(r = 0.343,p = 0.009),SBP与BMFI(r = 0.310,p = 0.019),DBP与WtHR(r = 0.368,p = 0.005),以及DBP与BMFI(r = 0.377,p = 0.004)。生化参数分析表明,除TG水平外,各组之间无显著差异,肥胖组的TG水平显著更高(p = 0.045)。

结论

尽管受试者的人体测量指标存在显著差异,但能量摄入和宏量营养素摄入并无显著差异。我们未发现两组之间大多数维生素或矿物质的摄入量存在显著差异。此外,维生素D、铁和硒等对整体健康至关重要的必需营养素摄入不足。两组均未达到推荐的叶酸摄入量,这可能会增加胎儿神经管缺陷的风险。

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