Wang Xiaochang, Wang Li, Wang Shoushi, Zhang Jinjie, Wang Xueyang, Zhang Ting, Li Linwei, Wei Jin, Zhao Yi, Zhou Zhixia
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao, China.
Department of Anesthesia and Perioperative Medicine, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China.
Front Immunol. 2025 Aug 1;16:1599674. doi: 10.3389/fimmu.2025.1599674. eCollection 2025.
The AP-1 transcription factor FOSL1, also known as Fra-1, is a crucial oncoprotein that plays an important role in human tumor progression and metastasis and has thus emerged as a promising therapeutic target. FOSL1 regulates the expression of a large protein-coding gene network, and this molecular mechanism can promote the progression of tumors. Interestingly, recent studies have shown that FOSL1 can also achieve the same protumor effect by regulating certain noncoding RNAs (ncRNAs). However, more studies have shown that ncRNAs can regulate the expression and activity of FOSL1, thereby affecting the occurrence and development of tumors, which indicates that ncRNAs can be regulators of FOSL1 in cancer. In this review, we first provide a comprehensive overview of the expression and function of FOSL1 and ncRNAs in tumors and then focus on the mutual regulatory relationship between ncRNAs and FOSL1, as well as their regulatory effects on and mechanisms of tumor progression. In addition, we further explored the potential clinical applications of the FOSL1-ncRNA system in cancer treatment, providing a theoretical basis for the study of FOSL1 and/or ncRNA-related molecular markers or targeted therapies.
AP-1转录因子FOSL1，也称为Fra-1，是一种关键的癌蛋白，在人类肿瘤进展和转移中起重要作用，因此已成为一个有前景的治疗靶点。FOSL1调节一个大型蛋白质编码基因网络的表达，这种分子机制可促进肿瘤进展。有趣的是，最近的研究表明，FOSL1还可通过调节某些非编码RNA（ncRNA）实现相同的促肿瘤作用。然而，更多研究表明，ncRNA可调节FOSL1的表达和活性，从而影响肿瘤的发生和发展，这表明ncRNA在癌症中可能是FOSL1的调节因子。在本综述中，我们首先全面概述FOSL1和ncRNA在肿瘤中的表达及功能，然后重点关注ncRNA与FOSL1之间的相互调节关系，以及它们对肿瘤进展的调节作用和机制。此外，我们进一步探讨了FOSL1-ncRNA系统在癌症治疗中的潜在临床应用，为FOSL1和/或ncRNA相关分子标志物或靶向治疗的研究提供理论依据。
