Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA 24060, USA.
Genes (Basel). 2023 Jul 11;14(7):1429. doi: 10.3390/genes14071429.
Non-coding RNAs (ncRNAs) are, arguably, the enigma of the RNA transcriptome. Even though there are more annotated ncRNAs (25,967) compared to mRNAs (19,827), we know far less about each of the genes that produce ncRNA, especially in terms of their regulation, molecular functions, and interactions. Further, we are only beginning to understand the role of differential regulation or function of ncRNAs caused by genetic and epigenetic perturbations, such as single nucleotide variants (SNV), deletions, insertions, and histone/DNA modifications. The 22 papers in this Special Issue describe the emerging roles of ncRNAs in neurological, cardiovascular, immune, and hepatic systems, to name a few, as well as in diseases such as cancer, Prader-Willi Syndrome, cardiac arrhythmias, and diabetes. As we begin to understand the function and regulation of this class of RNAs, strategies targeting ncRNAs could lead to improved therapeutic interventions for some conditions.
非编码 RNA(ncRNAs) 可以说是 RNA 转录组的谜团。尽管注释的 ncRNAs(25967 个)比 mRNAs(19827 个)多，但我们对产生 ncRNA 的每个基因的了解要少得多，特别是在它们的调控、分子功能和相互作用方面。此外，我们才刚刚开始了解遗传和表观遗传扰动(如单核苷酸变异(SNV)、缺失、插入和组蛋白/DNA 修饰)引起的 ncRNA 差异调控或功能的作用。本期特刊中的 22 篇论文描述了 ncRNAs 在神经、心血管、免疫和肝脏系统以及癌症、普拉德-威利综合征、心律失常和糖尿病等疾病中的新兴作用。随着我们开始理解这一类 RNA 的功能和调控，针对 ncRNAs 的策略可能会为某些疾病带来更好的治疗干预。
