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Editorial: Immune system interactions in hematological tumor microenvironments: pathways to innovative treatments.

作者信息

Mandato Elisa, Visentin Andrea

机构信息

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.

Hematology Unit, Department of Medicine, University of Padova, Padua, Italy.

出版信息

Front Immunol. 2025 Aug 1;16:1664847. doi: 10.3389/fimmu.2025.1664847. eCollection 2025.

DOI:10.3389/fimmu.2025.1664847
PMID:40821835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12354517/
Abstract
摘要

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本文引用的文献

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Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma.癌症特异性先天和适应性免疫重塑驱动经典型霍奇金淋巴瘤对程序性死亡受体1（PD-1）阻断治疗产生耐药。
Nat Commun. 2024 Dec 30;15(1):10740. doi: 10.1038/s41467-024-54512-7.
2
Advances in CAR-NK cell therapy for hematological malignancies.嵌合抗原受体自然杀伤细胞疗法治疗血液系统恶性肿瘤的研究进展。
Front Immunol. 2024 Jun 28;15:1414264. doi: 10.3389/fimmu.2024.1414264. eCollection 2024.
3
Protein kinase CK2α is overexpressed in classical hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may represent a new target for therapy.蛋白激酶 CK2α 在经典霍奇金淋巴瘤中过表达，调节关键信号通路、PD-L1，并可能成为新的治疗靶点。
Front Immunol. 2024 May 14;15:1393485. doi: 10.3389/fimmu.2024.1393485. eCollection 2024.
4
Tackling the dysregulated immune-checkpoints in classical Hodgkin lymphoma: bidirectional regulations between the microenvironment and Hodgkin/Reed-Sternberg cells.应对经典型霍奇金淋巴瘤中失调的免疫检查点：微环境与霍奇金/里德-斯腾伯格细胞之间的双向调节
Front Oncol. 2023 May 24;13:1203470. doi: 10.3389/fonc.2023.1203470. eCollection 2023.
5
Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022.造血细胞移植治疗血液系统疾病、实体瘤和免疫性疾病的适应证：2022 年欧洲的现行实践。
Bone Marrow Transplant. 2022 Aug;57(8):1217-1239. doi: 10.1038/s41409-022-01691-w. Epub 2022 May 19.
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PD-L1 Is Expressed and Promotes the Expansion of Regulatory T Cells in Acute Myeloid Leukemia.PD-L1 在急性髓系白血病中表达并促进调节性 T 细胞的扩增。
Front Immunol. 2020 Jul 31;11:1710. doi: 10.3389/fimmu.2020.01710. eCollection 2020.
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A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma.经典型霍奇金淋巴瘤患者对 PD-1 阻断治疗反应的外周免疫特征。
Nat Med. 2020 Sep;26(9):1468-1479. doi: 10.1038/s41591-020-1006-1. Epub 2020 Aug 10.
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p66Shc deficiency enhances CXCR4 and CCR7 recycling in CLL B cells by facilitating their dephosphorylation-dependent release from β-arrestin at early endosomes.p66Shc 缺乏通过促进 CLL B 细胞中 CXCR4 和 CCR7 在早期内涵体上依赖于去磷酸化从β-arrestin 上的释放，从而增强其再循环。
Oncogene. 2018 Mar;37(11):1534-1550. doi: 10.1038/s41388-017-0066-2. Epub 2018 Jan 12.
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Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells.套细胞淋巴瘤的免疫逃逸：B7-H1 的表达导致 T 细胞对肿瘤细胞的反应和杀伤受到抑制。
Haematologica. 2013 Sep;98(9):1458-66. doi: 10.3324/haematol.2012.071340. Epub 2013 Mar 18.