颞肌厚度可预测痴呆风险个体营养指标的变化：一项为期24周的纵向研究的见解。
Temporal muscle thickness predicts change in nutritional markers in individuals at risk of dementia: Insights from a 24-week longitudinal study.
作者信息
Salazar-Londoño Salomón, Pérez-Foucrier Valeria, Patricio Baldera Jonathan, Aarsland Markus, Venegas-Sanabria Luis Carlos, Borda Miguel German
机构信息
Semillero de Neurociencias y Envejecimiento, Aging Institute, Medical School, Pontificia Universidad Javeriana, Carrera 7#62-43, 110231, Bogotá, Colombia.
Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Gerd-Ragna Bloch Thorsens gate 8, 4011, Stavanger, Norway.
出版信息
JAR Life. 2025 Aug 8;14:100023. doi: 10.1016/j.jarlif.2025.100023. eCollection 2025.
OBJECTIVES
To investigate whether temporal muscle thickness (TMT) can serve as a predictor of change in nutritional widely used biomarkers in patients at risk of dementia.
DESIGN
Longitudinal observational study.
SETTING
Secondary analysis from a 24-week study conducted across three centers in Norway between 2018 and 2020.
PARTICIPANTS
Patients with mild cognitive impairment (MCI) or with two cardiometabolic disorders were included ( = 165).
MEASUREMENTS
Baseline and longitudinal statistical analysis were carried out to establish the association for outcomes (albumin, weight, C-Reactive Protein and Episodic Memory Quality) with TMT.
RESULTS
At baseline, there was a positive association between TMT and weight (Estimate=1.5157, = 0.009). At follow-up, positive associations were observed between TMT and albumin levels (Estimate=0.3031, = 0.048), as well as TMT and weight (Estimate=1.8954, = 0.001).
CONCLUSION
TMT is a possible accessible tool in clinical practice for monitoring health variables beyond cognitive decline in patients at risk of dementia.
目的
研究颞肌厚度（TMT）是否可作为痴呆风险患者营养广泛使用生物标志物变化的预测指标。
设计
纵向观察性研究。
背景
对2018年至2020年在挪威三个中心进行的一项为期24周的研究进行二次分析。
参与者
纳入轻度认知障碍（MCI）患者或患有两种心脏代谢疾病的患者（n = 165）。
测量
进行基线和纵向统计分析，以确定结局指标（白蛋白、体重、C反应蛋白和情景记忆质量）与TMT之间的关联。
结果
在基线时，TMT与体重之间存在正相关（估计值 = 1.5157，P = 0.009）。在随访时，观察到TMT与白蛋白水平之间存在正相关（估计值 = 0.3031，P = 0.048），以及TMT与体重之间存在正相关（估计值 = 1.8954，P = 0.001）。
结论
TMT可能是临床实践中一种可获取的工具，用于监测痴呆风险患者认知功能衰退以外的健康变量。
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