Dung Le Van, Son Pham Nguyen, Nguyen Kieu Ly Thi, Pho Dinh Cong, Thang Nguyen Manh, Thang Dao Chien, Son Pham Truong
Department of Cardiology, Duc Giang General Hospital, Hanoi, Vietnam.
Department of Cardiology, Heart Institute, 108 Military Central Hospital, Hanoi, Vietnam.
Vasc Health Risk Manag. 2025 Aug 11;21:607-615. doi: 10.2147/VHRM.S542595. eCollection 2025.
The cardio-ankle vascular index (CAVI) is an important metric for evaluating arterial stiffness (AS). In this study, we used cardio-ankle vascular index (CAVI) to predict CAD severity of coronary artery lesions.
This case-control study was conducted between October 2019 and December 2022. There were 222 patients divided into two groups: those with chronic coronary artery disease (CAD group), with 160 patients and a control group (non-CAD group) with 62 patients. The CAVI measurement and severity of coronary artery lesion parameters were evaluated (severity of stenosis, number of coronary artery diseases, syntax scores, and Gensini scores).
The CAVI in the CAD group (9.21 ± 0.79) was significantly higher than that in the non-CAD group (8.48 ± 0.62) (p < 0.001). CAVI, with a cut-off point ≥8.83, was a significant predictor of chronic CAD (OR = 9.6; 95% CI: 4.0-18.8) with an area under the curve (AUC) of 0.796 (95% CI: 0.736-0.856; p < 0.001). CAVI was significantly higher in severe stenosis (≥75%) compared to moderate stenosis (9.41 ± 0.81 vs 9.02 ± 0.75, p = 0.002). CAVI was higher in multivessel disease compared to single-vessel disease (9.43 ± 0.80 vs 8.90 ± 0.70, p < 0.001). CAVI increased with higher SYNTAX scores (mild, moderate, and severe: 9.09 ± 0.65, 9.80 ± 1.05, and 9.45 ± 0.46, respectively; p < 0.001) and Gensini scores (mild, moderate, and severe: 8.90 ± 0.65, 9.37 ± 0.95, and 9.43 ± 0.59, respectively; p < 0.001).
CAVI is higher in chronic CAD and can predict chronic CAD with a cut-off point of ≥8.83. The CAVI is higher in patients with severe stenosis, multivessel coronary artery disease, higher syntax scores, and higher Gensini scores.
心踝血管指数（CAVI）是评估动脉僵硬度（AS）的一项重要指标。在本研究中，我们使用心踝血管指数（CAVI）来预测冠状动脉病变的CAD严重程度。
本病例对照研究于2019年10月至2022年12月进行。222例患者分为两组：慢性冠状动脉疾病患者（CAD组）160例，对照组（非CAD组）62例。评估CAVI测量值和冠状动脉病变参数的严重程度（狭窄程度、冠状动脉疾病数量、SYNTAX评分和Gensini评分）。
CAD组的CAVI（9.21±0.79）显著高于非CAD组（8.48±0.62）（p<0.001）。CAVI截断点≥8.83是慢性CAD的显著预测指标（OR=9.6；95%CI：4.0-18.8），曲线下面积（AUC）为0.796（95%CI：0.736-0.856；p<0.001）。与中度狭窄相比，严重狭窄（≥75%）时CAVI显著更高（9.41±0.81对9.02±0.75，p=0.002）。多支血管病变患者的CAVI高于单支血管病变患者（9.43±0.80对8.90±0.70，p<0.001）。CAVI随着SYNTAX评分升高而增加（轻度、中度和重度分别为：9.09±0.65、9.80±1.05和9.45±0.46；p<0.001）以及Gensini评分升高而增加（轻度、中度和重度分别为：8.90±0.65、9.37±0.95和9.43±0.59；p<0.001）。
慢性CAD患者的CAVI更高，截断点≥8.83时可预测慢性CAD。严重狭窄、多支冠状动脉病变、较高SYNTAX评分和较高Gensini评分患者的CAVI更高。
