Baidarbekov Murat U, Bekarisov Olzhas S, Ipmagambetov Zhangir N, Abdigalikov Margulan S, Akimbekov Agzam A
National Scientific Center of Traumatology and Orthopedics Named After Academician N.D. Batpenov, Astana, Kazakhstan.
Medical University of Karaganda, Karaganda, Kazakhstan.
Clin Med Insights Case Rep. 2025 Aug 15;18:11795476251357427. doi: 10.1177/11795476251357427. eCollection 2025.
Lumbar interbody fusion (LIF) is a widely used surgical technique for treating degenerative spinal conditions. However, challenges such as pseudarthrosis and implant migration remain significant concerns. This case report presents the use of a novel trabecular titanium cage combined with a biocomposite hydrogel containing stromal-vascular fraction and BMP-2 to enhance osseointegration and accelerate bone fusion.
A 61-year-old female patient with severe chronic lumbar pain, functional impairment, and grade II anterolisthesis of L4 underwent lumbar interbody fusion. A custom-designed trabecular titanium cage was implanted, featuring an optimized porous structure for enhanced fixation and bone ingrowth. To further promote bone regeneration, a biocomposite hydrogel synthesized from adipose-derived stromal-vascular fraction and BMP-2 was applied. Postoperative assessment demonstrated significant pain reduction, improved functional activity, and early bone fusion formation. Radiological imaging confirmed stable implant positioning, progressive trabecularization, and successful osseointegration. No complications, such as implant migration or material loosening, were observed.
This case highlights the potential benefits of combining advanced implant design with bioactive materials in spinal fusion surgery. The approach resulted in early and stable bone integration, reduced pain, and improved functional recovery. Further studies with larger patient cohorts and extended follow-up periods are needed to validate these findings and assess long-term outcomes.
腰椎椎间融合术（LIF）是一种广泛用于治疗脊柱退行性疾病的外科技术。然而，诸如假关节形成和植入物移位等挑战仍然是重大问题。本病例报告介绍了使用一种新型小梁钛笼结合一种含有基质血管成分和骨形态发生蛋白-2（BMP-2）的生物复合水凝胶来增强骨整合并加速骨融合。
一名61岁女性患者，患有严重的慢性腰痛、功能障碍以及L4椎体II度前滑脱，接受了腰椎椎间融合术。植入了一个定制设计的小梁钛笼，其具有优化的多孔结构以增强固定和骨长入。为进一步促进骨再生，应用了一种由脂肪来源的基质血管成分和BMP-2合成的生物复合水凝胶。术后评估显示疼痛显著减轻、功能活动改善以及早期骨融合形成。影像学检查证实植入物位置稳定、小梁逐渐形成且骨整合成功。未观察到诸如植入物移位或材料松动等并发症。
本病例突出了在脊柱融合手术中将先进的植入物设计与生物活性材料相结合的潜在益处。该方法导致早期且稳定的骨整合、疼痛减轻以及功能恢复改善。需要对更大的患者队列进行进一步研究并延长随访期，以验证这些发现并评估长期结果。
