• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Beyond the needle: how clinician expertise affects outcomes in the treatment of hemifacial spasm.超越针头:临床医生的专业技能如何影响半面痉挛的治疗结果。
Clin Park Relat Disord. 2025 Aug 6;13:100383. doi: 10.1016/j.prdoa.2025.100383. eCollection 2025.
2
Prescription of Controlled Substances: Benefits and Risks管制药品的处方:益处与风险
3
[Volume and health outcomes: evidence from systematic reviews and from evaluation of Italian hospital data].[容量与健康结果:来自系统评价和意大利医院数据评估的证据]
Epidemiol Prev. 2013 Mar-Jun;37(2-3 Suppl 2):1-100.
4
Botulinum toxin type B for cervical dystonia.用于治疗颈部肌张力障碍的B型肉毒毒素
Cochrane Database Syst Rev. 2005 Jan 25(1):CD004315. doi: 10.1002/14651858.CD004315.pub2.
5
The Black Book of Psychotropic Dosing and Monitoring.《精神药物剂量与监测黑皮书》
Psychopharmacol Bull. 2024 Jul 8;54(3):8-59.
6
Botulinum toxins for the prevention of migraine in adults.用于预防成人偏头痛的肉毒杆菌毒素。
Cochrane Database Syst Rev. 2018 Jun 25;6(6):CD011616. doi: 10.1002/14651858.CD011616.pub2.
7
Eliciting adverse effects data from participants in clinical trials.从临床试验参与者中获取不良反应数据。
Cochrane Database Syst Rev. 2018 Jan 16;1(1):MR000039. doi: 10.1002/14651858.MR000039.pub2.
8
Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation.侵入性尿动力学检查在难治性膀胱过度活动症女性患者管理中的应用:FUTURE,一项优效性随机对照试验及经济学评估
Health Technol Assess. 2025 Jul;29(27):1-139. doi: 10.3310/UKYW4923.
9
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.系统性药理学治疗慢性斑块状银屑病:网络荟萃分析。
Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD011535. doi: 10.1002/14651858.CD011535.pub4.
10
Sexual Harassment and Prevention Training性骚扰与预防培训

本文引用的文献

1
Efficacy and safety of botulinum neurotoxin in the treatment of hemifacial spasms: a systematic review and meta-analysis.肉毒毒素治疗半面痉挛的疗效和安全性:系统评价和荟萃分析。
BMC Neurol. 2024 Oct 29;24(1):420. doi: 10.1186/s12883-024-03883-x.
2
Botulinum toxin treatment for hemifacial spasm: harmonising neurological and aesthetic outcomes.肉毒杆菌毒素治疗面肌痉挛:协调神经学和美学效果。
J Neural Transm (Vienna). 2025 Jan;132(1):23-38. doi: 10.1007/s00702-024-02821-y. Epub 2024 Aug 23.
3
Facial phantom model: a low-cost and safe tool for teaching botulinum toxin application in neurology residencies.面部赝复模型:一种用于神经病学住院医师培训中肉毒毒素应用教学的低成本、安全工具。
Arq Neuropsiquiatr. 2024 Jan;82(1):1-6. doi: 10.1055/s-0044-1779037. Epub 2024 Jan 29.
4
Medical Education: Patients' Perspectives on Clinical Training and Informed Consent.医学教育:患者对临床培训和知情同意的看法。
Int J Environ Res Public Health. 2022 Jun 22;19(13):7611. doi: 10.3390/ijerph19137611.
5
Does the "July effect" of new trainees at teaching hospitals impact outcomes for patients hospitalized with heart failure? Real-world analyses of more than half a million US admissions.教学医院新实习生的“七月效应”是否会影响心力衰竭住院患者的治疗结果?对超过50万例美国住院病例的真实世界分析。
Am Heart J Plus. 2022 Jan;13. doi: 10.1016/j.ahjo.2021.100072. Epub 2021 Nov 27.
6
July Effect in Obstetric Outcomes.产科结局中的“七月效应”
Int J Womens Health. 2022 Feb 9;14:149-154. doi: 10.2147/IJWH.S341044. eCollection 2022.
7
Reassessing the July Effect: 30 Years of Evidence Show No Difference in Outcomes.重新评估“七月效应”:30 年的证据表明,结果并无差异。
Ann Surg. 2023 Jan 1;277(1):e204-e211. doi: 10.1097/SLA.0000000000004805. Epub 2021 Feb 25.
8
Hemifacial spasm through the last three decades: From etiology to efficacy and safety of long-term botulinum toxin treatment.面肌痉挛近三十年:从病因到肉毒毒素长期治疗的疗效和安全性。
Clin Neurol Neurosurg. 2021 Apr;203:106555. doi: 10.1016/j.clineuro.2021.106555. Epub 2021 Feb 10.
9
Botulinum toxin type A therapy for hemifacial spasm.A型肉毒杆菌毒素治疗面肌痉挛
Cochrane Database Syst Rev. 2020 Nov 19;11(11):CD004899. doi: 10.1002/14651858.CD004899.pub3.
10
Which factors impact on quality of life for adults with blepharospasm and hemifacial spasm?哪些因素会影响眼睑痉挛和半面痉挛成人的生活质量?
Orbit. 2021 Apr;40(2):110-119. doi: 10.1080/01676830.2020.1733028. Epub 2020 Mar 1.

超越针头:临床医生的专业技能如何影响半面痉挛的治疗结果。

Beyond the needle: how clinician expertise affects outcomes in the treatment of hemifacial spasm.

作者信息

Luque-Llano Melissa, Angelica-Coronel Maria, Alvarado-Vanegas Yulexy T, Puello Floralinda García, Ortega Laura Arzuza, Vincos Gustavo B

机构信息

Department of Neurology Universidad Simón Bolívar, Health sciences faculty, Barranquilla 080001, Colombia.

Universidad Simón Bolívar, Health Sciences Faculty, Barranquilla 080001, Colombia.

出版信息

Clin Park Relat Disord. 2025 Aug 6;13:100383. doi: 10.1016/j.prdoa.2025.100383. eCollection 2025.

DOI:10.1016/j.prdoa.2025.100383
PMID:40823673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12355150/
Abstract

BACKGROUND

Hemifacial spasm (HFS) is characterized by abnormal contraction of the muscles innervated by the seventh cranial nerve. It is usually benign and diagnosed clinically. The effectiveness of botulinum toxin (BoNT) for its treatment has been well demonstrated. However, adverse events (AEs) resulting from its administration remain a concern, and some patients express reluctance to be treated by resident physicians, even when under expert supervision.

OBJECTIVE

To determine the association between the level of expertise of the neurology professional and the presence of AEs following BoNT administration in patients with HFS.

METHODS

A cross-sectional descriptive study with an analytical phase conducted at Hospital Occidente de Kennedy (Bogotá, Colombia). Out of 88 medical records reviewed, 73 met all inclusion criteria. Data analysis was performed using SPSS software version 22.

RESULTS

A predominance of female patients was observed, accounting for 74 % of the study population. The mean age of symptom onset was 54.5 ± 12.7 years, with a median symptom duration of 9 years. In most cases, the left side was affected (53.4 %). The average number of botulinum toxin applications per patient was 2.6 during the study period. Adverse events occurred in 12.6 % of cases, primarily mild facial paresis (7.9 %), hematoma (2.6 %), and eyelid ptosis (2.1 %).

CONCLUSIONS

The results did not show a statistically significant association between the level of expertise and the occurrence of adverse events. The frequency of observed adverse events was similar between the groups. This suggests that the occurrence of adverse events following BoNT administration was comparable regardless of whether the procedure was performed by a neurologist or a resident under supervision.

摘要

背景

面肌痉挛(HFS)的特征是由第七对脑神经支配的肌肉出现异常收缩。它通常为良性,通过临床诊断。肉毒杆菌毒素(BoNT)治疗该病的有效性已得到充分证实。然而,其注射引起的不良事件(AE)仍是一个问题,一些患者即使在专家监督下,也不愿接受住院医师的治疗。

目的

确定神经科专业人员的专业水平与HFS患者注射BoNT后不良事件发生之间的关联。

方法

在肯尼迪西部医院(哥伦比亚波哥大)进行了一项带有分析阶段的横断面描述性研究。在审查的88份病历中,73份符合所有纳入标准。使用SPSS 22版软件进行数据分析。

结果

观察到女性患者占优势,占研究人群的74%。症状出现的平均年龄为54.5±12.7岁,症状持续时间中位数为9年。在大多数情况下,左侧受累(53.4%)。在研究期间,每位患者肉毒杆菌毒素的平均注射次数为2.6次。12.6%的病例发生了不良事件,主要是轻度面部轻瘫(7.9%)、血肿(2.6%)和眼睑下垂(2.1%)。

结论

结果未显示专业水平与不良事件发生之间存在统计学上的显著关联。各组观察到的不良事件发生率相似。这表明,无论手术是由神经科医生还是在监督下的住院医师进行,注射BoNT后不良事件的发生情况相当。