Ali B H, Hassan T, Suliman H B, Abdelsalam E B
Vet Hum Toxicol. 1985 Dec;27(6):477-80.
Clinically normal Nubian goats were given the antiprotozoal drug imidocarb at single intramuscular doses of 6, 12, 18 and 24 mg/kg, and the various clinical, biochemical and pathological manifestations were recorded. At a dose of 6 mg/kg the drug produced no change in any of the parameters studied. At higher doses, the drug produced dose dependent changes which included increased heart and respiratory rates, increased defaecation, urination, depression, incoordination of movement, weakness of the hindlegs, recumbency, and finally death. Just prior to death, there was a significant decrease in the number of erythrocytes, and in packed cell volume, and haemoglobin concentration. In plasma there was an increase in the activity of aspartate transaminase, urea and creatinine concentrations and inhibition of cholinesterase activity. The main histopathological changes were associated with hepatic and renal damage. Three goats were pre-treated with atropine sulphate (1 mg/animal) and after one hour given imidocarb intramuscularly at a dose of 12 mg/kg. The changes were similar but much less severe when compared with those in animals given imidocarb alone at the same dose.
给临床正常的努比亚山羊单次肌内注射剂量为6、12、18和24毫克/千克的抗寄生虫药物咪唑苯脲，并记录各种临床、生化和病理表现。剂量为6毫克/千克时，该药物在所研究的任何参数上均未产生变化。在较高剂量下，该药物产生剂量依赖性变化，包括心率和呼吸频率增加、排便和排尿增多、抑郁、运动不协调、后腿无力、卧地，最终死亡。就在死亡前，红细胞数量、血细胞比容和血红蛋白浓度显著下降。血浆中天冬氨酸转氨酶活性、尿素和肌酐浓度升高，胆碱酯酶活性受到抑制。主要组织病理学变化与肝和肾损伤有关。三只山羊先用硫酸阿托品（1毫克/只动物）预处理，1小时后肌内注射剂量为12毫克/千克的咪唑苯脲。与以相同剂量单独给予咪唑苯脲的动物相比，变化相似但严重程度要轻得多。
