Adams L G
Res Vet Sci. 1981 Jul;31(1):54-61.
Six groups of four adult horses were twice injected intramuscularly at a 24 hour interval with 0, 2, 4, 8, 16 or 32 mg/kg of imidocarb dipropionate (IMDP) and monitored for 21 days. The LD50 of IMDP for 21 days after injection was two doses of 15.99 +/- 1.49 mg/kg with mortalities occurring within six days following the first injection. Increasing levels of IMDP were correlated with increasing rates of morbidity, mortality, local and systemic reactions, increasing levels of blood urea nitrogen, serum aspartate amino transferase, serum sorbitol dehydrogenase, serum creatine phosphokinase, neutrophilia and increasing severity of renal, hepatic and pulmonary lesions. Mortalities were attributed to acute renal cortical tubular necrosis and acute periportal hepatic necrosis induced by two injections of 16 or 32 mg/kg of IMDP.
将六组每组四匹成年马，以24小时间隔进行两次肌肉注射，注射剂量分别为0、2、4、8、16或32毫克/千克的双丙酸咪唑苯脲（IMDP），并监测21天。注射后21天IMDP的半数致死剂量为两剂15.99±1.49毫克/千克，死亡发生在首次注射后的六天内。IMDP水平的升高与发病率、死亡率、局部和全身反应率的增加、血尿素氮、血清天冬氨酸氨基转移酶、血清山梨醇脱氢酶、血清肌酸磷酸激酶水平的升高、嗜中性粒细胞增多以及肾、肝和肺病变严重程度的增加相关。死亡归因于两次注射16或32毫克/千克IMDP引起的急性肾皮质肾小管坏死和急性肝门周围肝坏死。
