Eslamifar Zahra, Manucheri Farzaneh, Ghanbari Saeed, Zandi Mohammadreza, Sabbagh Susan
Department of Medical Laboratory Sciences, School of Paramedical Sciences, Dezful University of Medical Sciences, Dezful, Iran.
Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran.
Ir J Med Sci. 2025 Aug 18. doi: 10.1007/s11845-025-04009-z.
The study investigates the effects of royal jelly (RJ) on patients with relapsing-remitting multiple sclerosis (RRMS), focusing on its potential to reduce oxidative stress, improve antioxidant levels, and enhance quality of life.
A total of 61 RRMS patients were randomly assigned to either a RJ group or a placebo group, receiving a daily dose of 500 mg for 45 days. Key outcomes measured included expanded disability status scale (EDSS) scores, levels of malondialdehyde (MDA), and activities of antioxidants such as catalase (CAT) and superoxide dismutase (SOD), along with assessments of fatigue and quality of life.
Results indicated that the RJ group experienced a significant reduction in EDSS scores (P < 0.001) and MDA levels (P < 0.0001). The activity of SOD and CAT after consumption of RJ had increased significantly (P < 0.0001, P < 0.001), respectively. Additionally, improvements were noted in some parameters of fatigue and quality of life measures.
The findings suggest that RJ may help decrease oxidative stress and improve motor function and anti-oxidant capacity in MS patients, potentially slowing disease progression.
This study was registered on the Iranian Registry of Clinical Trials (Registration No. IRCT20220116053732N1) on 2022.05.08.
本研究调查了蜂王浆（RJ）对复发缓解型多发性硬化症（RRMS）患者的影响，重点关注其降低氧化应激、提高抗氧化水平和改善生活质量的潜力。
总共61例RRMS患者被随机分为RJ组或安慰剂组，每天服用500毫克，持续45天。测量的主要结果包括扩展残疾状态量表（EDSS）评分、丙二醛（MDA）水平以及过氧化氢酶（CAT）和超氧化物歧化酶（SOD）等抗氧化剂的活性，同时评估疲劳和生活质量。
结果表明，RJ组的EDSS评分（P < 0.001）和MDA水平（P < 0.0001）显著降低。服用RJ后，SOD和CAT的活性分别显著增加（P < 0.0001，P < 0.001）。此外，疲劳和生活质量测量的一些参数也有所改善。
研究结果表明，RJ可能有助于降低MS患者的氧化应激，改善运动功能和抗氧化能力，可能减缓疾病进展。
本研究于2022年5月8日在伊朗临床试验注册中心注册（注册号：IRCT20220116053732N1）。
