Gong Yuan, Luo Hongjie, Li Zeju, Feng Yijun, Liu Zhen, Chang Jie
Department of Occupational and Environmental Health, School of Public Health, Soochow University, 199 Ren'ai Road, Suzhou 215123, China.
Metabolites. 2023 Aug 18;13(8):954. doi: 10.3390/metabo13080954.
Alzheimer's disease (AD) represents a significant public health concern in modern society. Metabolic syndrome (MetS), which includes diabetes mellitus (DM) and obesity, represents a modifiable risk factor for AD. MetS and AD are interconnected through various mechanisms, such as mitochondrial dysfunction, oxidative stress, insulin resistance (IR), vascular impairment, inflammation, and endoplasmic reticulum (ER) stress. Therefore, it is necessary to seek a multi-targeted and safer approach to intervention. Thus, 10-hydroxy-2-decenoic acid (10-HDA), a unique hydroxy fatty acid in royal jelly, has shown promising anti-neuroinflammatory, blood-brain barrier (BBB)-preserving, and neurogenesis-promoting properties. In this paper, we provide a summary of the relationship between MetS and AD, together with an introduction to 10-HDA as a potential intervention nutrient. In addition, molecular docking is performed to explore the metabolic tuning properties of 10-HDA with associated macromolecules such as GLP-1R, PPARs, GSK-3, and TREM2. In conclusion, there is a close relationship between AD and MetS, and 10-HDA shows potential as a beneficial nutritional intervention for both AD and MetS.
阿尔茨海默病（AD）是现代社会中一个重大的公共卫生问题。代谢综合征（MetS），包括糖尿病（DM）和肥胖，是AD的一个可改变的风险因素。MetS和AD通过多种机制相互关联，如线粒体功能障碍、氧化应激、胰岛素抵抗（IR）、血管损伤、炎症和内质网（ER）应激。因此，有必要寻求一种多靶点且更安全的干预方法。因此，10-羟基-2-癸烯酸（10-HDA），一种蜂王浆中独特的羟基脂肪酸，已显示出有前景的抗神经炎症、保护血脑屏障（BBB）和促进神经发生的特性。在本文中，我们总结了MetS与AD之间的关系，并介绍了10-HDA作为一种潜在的干预营养素。此外，进行了分子对接以探索10-HDA与相关大分子如胰高血糖素样肽-1受体（GLP-1R）、过氧化物酶体增殖物激活受体（PPARs）、糖原合成酶激酶-3（GSK-3）和触发受体表达于髓细胞2（TREM2）的代谢调节特性。总之，AD与MetS之间存在密切关系，10-HDA显示出作为对AD和MetS均有益的营养干预的潜力。
