Tear Alveron Andreas, Rivaldo Rafly Mochamad, Oehadian Amaylia, Wirawan Chevie, Darmawan Guntur, Mardia Andri Iskandar, Sahiratmadja Edhyana, Hamijoyo Laniyati
Faculty of Medicine, Universitas Padjadjaran, Indonesia.
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
Ann Med. 2025 Dec;57(1):2545555. doi: 10.1080/07853890.2025.2545555. Epub 2025 Aug 18.
Tuberculosis (TB) is one of the most common infectious diseases in patients with systemic lupus erythematosus (SLE) and often has severe and devastating manifestations. This study aimed to systematically investigate the association between organ involvement and laboratory abnormalities in patients with systemic lupus erythematosus (SLE) associated with tuberculosis disease (TB).
Relevant studies were obtained from electronic databases, including PubMed, Scopus, Science Direct, and EBSCO from inception to November 2024. The primary outcome was the odds ratio (OR) of TB incidence associated with organ involvement and laboratory abnormalities. Quality of studies was assessed using the Newcastle-Ottawa Scale (NOS). A meta-analysis was performed using R.
Fourteen studies with a total of 5,626 adult SLE patients were included, of whom 514 (9.14%) were male. Renal involvement was the only organ involvement that was significantly associated with TB (OR = 1.53; 95%CI:1.01-2.32; =76%). Among laboratory parameters, lymphopenia (OR = 2.21; 95%CI:1.42-3.42; =26%) and anemia (OR = 1.73; 95%CI:1.16-2.58; =21%) showed a significant association with TB. No significant associations were found for other organs or laboratory abnormalities.
Renal involvement, lymphopenia, and anemia could be notable risk factors for TB in patients with SLE, suggesting enhanced awareness of these indicators to minimize the risk of TB in patients with SLE.
结核病（TB）是系统性红斑狼疮（SLE）患者中最常见的传染病之一，且往往具有严重和毁灭性的表现。本研究旨在系统调查合并结核病（TB）的系统性红斑狼疮（SLE）患者的器官受累情况与实验室异常之间的关联。
从电子数据库中获取相关研究，包括自数据库建立至2024年11月的PubMed、Scopus、Science Direct和EBSCO。主要结局是与器官受累和实验室异常相关的结核病发病的比值比（OR）。使用纽卡斯尔-渥太华量表（NOS）评估研究质量。使用R进行荟萃分析。
纳入了14项研究，共5626例成年SLE患者，其中514例（9.14%）为男性。肾脏受累是唯一与结核病显著相关的器官受累情况（OR = 1.53；95%CI：1.01 - 2.32；P = 76%）。在实验室参数中，淋巴细胞减少（OR = 2.21；95%CI：1.42 - 3.42；P = 26%）和贫血（OR = 1.73；95%CI：1.16 - 2.58；P = 21%）与结核病显著相关。未发现其他器官或实验室异常存在显著关联。
肾脏受累、淋巴细胞减少和贫血可能是SLE患者发生结核病的显著危险因素，这表明应提高对这些指标的认识，以尽量降低SLE患者发生结核病的风险。
