Poudel Ranjita, Yang Min-Jeong, Dougan Skye O, Yates Helen, Brown Bradley, Washington Sierra, Satardekar Aarya P, Haver Mary Katherine, Vinci Christine
Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, United States of America.
Institute for Nicotine and Tobacco Studies, Rutgers Biomedical and Health Sciences (Rutgers Health), Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States of America.
PLoS One. 2025 Aug 18;20(8):e0330323. doi: 10.1371/journal.pone.0330323. eCollection 2025.
Caregivers of Hematopoietic Stem Cell Transplant (HSCT) recipients bear significant responsibilities involving commitment to be available 24/7, up to at least 100 days post-transplant or longer, and to provide emotional and physical support to the recipient. This extended caregiving, along with managing all other household responsibilities, can result in an increased caregiver burden, which is associated with reduced quality of life (QoL) and compromised psychological, and physical well-being. In recent years, there has been increased attention to interventions addressing the mental health outcomes of caregivers of HSCT patients. However, there remains a limited understanding of the feasibility and effectiveness of existing interventions targeted to this population. This review aims to systematically evaluate existing psychological interventions for caregivers of HSCT patients and report on: 1) the feasibility and acceptability of these interventions, and 2) the efficacy of these interventions on caregivers' psychological outcomes. A systematic literature search for studies evaluating psychological interventions targeted to caregivers of HSCT patients was conducted in English through the following databases: Ovid MEDLINE (Wolters Kluwer), Embase (Elsevier), CINAHL Complete (EBSCO), APA PsycArticles (EBSCO), APA PsycInfo (EBSCO). Two reviewers will independently identify the studies, extract relevant data, and conduct quality and risk of bias assessments. Discrepancies in coding will be discussed between the two reviewers, and a third reviewer will resolve pending disagreements. Within the systematic review, all eligible studies will be summarized descriptively. If data allows, we will further utilize meta-analysis to quantitatively evaluate the efficacy of these psychological interventions tested in RCTs. The association between intervention type, modality, duration, and efficacy will be assessed via subgroup analysis. Ethics approval is not required as this study will only include secondary data from already published studies. The outcomes will be shared through scientific conferences and peer-reviewed publications. This protocol is registered in PROSPERO: CRD42024489695.
造血干细胞移植（HSCT）受者的照顾者承担着重大责任，包括承诺全天候随时待命，移植后至少100天或更长时间，为受者提供情感和身体支持。这种长期的照顾，再加上处理所有其他家庭责任，可能会导致照顾者负担加重，这与生活质量（QoL）下降以及心理和身体健康受损有关。近年来，针对HSCT患者照顾者心理健康结果的干预措施受到了越来越多的关注。然而，对于针对这一人群的现有干预措施的可行性和有效性，人们的了解仍然有限。本综述旨在系统评价针对HSCT患者照顾者的现有心理干预措施，并报告：1）这些干预措施的可行性和可接受性，以及2）这些干预措施对照顾者心理结果的疗效。通过以下英文数据库对评估针对HSCT患者照顾者的心理干预措施的研究进行了系统的文献检索：Ovid MEDLINE（Wolters Kluwer）、Embase（Elsevier）、CINAHL Complete（EBSCO）、APA PsycArticles（EBSCO）、APA PsycInfo（EBSCO）。两名评审员将独立识别研究、提取相关数据，并进行质量和偏倚风险评估。编码差异将在两名评审员之间进行讨论，第三名评审员将解决悬而未决的分歧。在系统评价中，将对所有符合条件的研究进行描述性总结。如果数据允许，我们将进一步利用荟萃分析对随机对照试验中测试的这些心理干预措施的疗效进行定量评估。将通过亚组分析评估干预类型、方式、持续时间和疗效之间的关联。由于本研究仅包括已发表研究的二手数据，因此无需伦理批准。研究结果将通过科学会议和同行评审出版物分享。本方案已在PROSPERO注册：CRD42024489695。
