溴隐亭对甲状腺功能减退症患者促甲状腺激素（TSH）、催乳素（Pr）、人生长激素（HGH）、甲状腺素（T4）和三碘甲状腺原氨酸（T3）分泌的影响。
Effect of bromocryptine on the secretion of thyrotropic hormone (TSH), prolactin (Pr), human growth hormone (HGH), thyroxine (T4) and triiodothyroxine (T3) in hypothyroidism.
作者信息
Felt V, Nedvdková J
出版信息
Horm Metab Res. 1977 Jul;9(4):274-7. doi: 10.1055/s-0028-1093551.
PMID:408253
Abstract
Bromocryptine (CB-154) virtually abolished the rise of serum Pr after TRH stimulation in hypothyroid and euthyroid subjects. The response of serum TSH to TRH stimulation was significantly depressed in hypothyroid but not in euthyroid subjects. No significant changes of serum HGH, T4 and T3 after CB-154 were observed. The dual mode of action of CB-154 in pituitary and hypothalamus is discussed.
摘要
在甲状腺功能减退和甲状腺功能正常的受试者中，溴隐亭（CB - 154）几乎完全消除了促甲状腺激素释放激素（TRH）刺激后血清催乳素（Pr）的升高。在甲状腺功能减退的受试者中，血清促甲状腺激素（TSH）对TRH刺激的反应显著降低，但在甲状腺功能正常的受试者中则没有。未观察到CB - 154后血清生长激素（HGH）、甲状腺素（T4）和三碘甲状腺原氨酸（T3）有显著变化。文中讨论了CB - 154在垂体和下丘脑的双重作用模式。
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