Nedvídková J, Felt V
Endokrinologie. 1976;68(2):175-82.
After peroral administration of TRH there were found elevated responses of TSH and HPr in hypothyroidism but not in hyperthyroidism. While the basal levels of TSH were elevated in hypothyroidism and depressed in hyperthyroidism, no such difference has been found in the case of basal levels of HPr. After TRH stimulation the levels of HGH decreased especially in hyperthyroidism; in patients with acromegaly serum HGH level increased after TRH. Serum T4 increased only in euthyroid persons after 2 and especially 24 hours, but not in hyperthyroidism or hypothyroidism. Mean values of serum T3 were elevated after TRH in all three groups, but the difference was significant only in euthyroid subjects. FT4I was increased in euthyroid person after TRH stimulation.
经口给予促甲状腺激素释放激素（TRH）后，发现甲状腺功能减退症患者的促甲状腺激素（TSH）和高泌乳素（HPr）反应升高，而甲状腺功能亢进症患者则无此反应。虽然甲状腺功能减退症患者的TSH基础水平升高，甲状腺功能亢进症患者的TSH基础水平降低，但在HPr基础水平方面未发现此类差异。TRH刺激后，生长激素（HGH）水平下降，尤其是在甲状腺功能亢进症患者中；肢端肥大症患者在TRH刺激后血清HGH水平升高。仅在甲状腺功能正常者中，血清总甲状腺素（T4）在2小时尤其是24小时后升高，而在甲状腺功能亢进症或甲状腺功能减退症患者中未升高。三组患者在TRH刺激后血清总三碘甲状腺原氨酸（T3）的平均值均升高，但仅在甲状腺功能正常者中差异有统计学意义。TRH刺激后，甲状腺功能正常者的游离甲状腺素指数（FT4I）升高。
