Ahn Ji-Seon, Kim Hae-Mi, Han Eui-Jeong, Hong Seong-Tshool, Chung Hea-Jong
Gwangju Center, Korea Basic Science Institute, Gwangju, 61751, Republic of Korea.
Department of Biomedical Sciences, Jeonbuk National University Medical School, Jeonju, Jeollabuk-do, 54907, Republic of Korea.
Sci Rep. 2025 Aug 18;15(1):30179. doi: 10.1038/s41598-025-15222-2.
This study provides the first evidence related to the identification of microbial strains closely associated with muscle strength enhancement, independent of the host's genetic background. Fecal transplants from humans into mice revealed a significant impact of gut bacteria on muscle strength, with some mice experiencing increases, while others showed no change or decreases. Interestingly, analysis of the fecal and gastrointestinal tract bacteria from each mouse classified by the degree of muscle strength revealed significant differences based on muscle strength. Furthermore, a more diverse microbial community was observed in the gastrointestinal tract compared to the feces. Further investigation identified two bacterial species, Lactobacillus johnsonii (L. johnsonii) and Limosilactobacillus reuteri (L. reuteri), that are related to improved muscle strength. Indeed, we confirmed that the supplementation with these bacteria in aged mice significantly enhanced their muscle strength by increasing the mRNA expression levels of follistatin (FST) and insulin-like growth factor-1 (IGF1) in muscle tissue. Overall, this study provides the first evidence that specific gut bacteria can directly improve muscle strength and introduces a novel approach to studying the gut microbiome's influence on complex traits.
本研究提供了首个与识别独立于宿主遗传背景、与肌肉力量增强密切相关的微生物菌株相关的证据。将人类粪便移植到小鼠体内显示，肠道细菌对肌肉力量有显著影响，一些小鼠肌肉力量增加，而另一些则没有变化或下降。有趣的是，对每只小鼠按肌肉力量程度分类的粪便和胃肠道细菌进行分析，发现基于肌肉力量存在显著差异。此外，与粪便相比，在胃肠道中观察到更多样化的微生物群落。进一步调查确定了两种细菌，约氏乳杆菌（L. johnsonii）和罗伊氏乳杆菌（L. reuteri），它们与肌肉力量改善有关。事实上，我们证实，在老年小鼠中补充这些细菌可通过提高肌肉组织中卵泡抑素（FST）和胰岛素样生长因子-1（IGF1）的mRNA表达水平，显著增强它们的肌肉力量。总体而言，本研究提供了首个证据，证明特定肠道细菌可直接改善肌肉力量，并引入了一种研究肠道微生物群对复杂性状影响的新方法。
