极早产儿高血糖与矫正年龄18个月时神经发育结局的关联
Association of hyperglycemia in extremely preterm infants with neurodevelopmental outcomes at 18 months of corrected age.
作者信息
Minamitani Yohei, Nakajima Kazusa, Namba Fumihiko
机构信息
Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
出版信息
J Perinatol. 2025 Aug 18. doi: 10.1038/s41372-025-02388-w.
OBJECTIVE
To investigate the impact of hyperglycemia on the neurodevelopmental outcomes in extremely preterm infants.
STUDY DESIGN
This single-center retrospective cohort study enrolled extremely preterm infants born at <28 weeks of gestation. Hyperglycemia was defined as a blood glucose level of >15 mmol/L. The Kyoto Scale of Psychological Development at 18 months of corrected age was used for neurodevelopmental assessment, and a developmental quotient (DQ) of ≥85 was defined as normal.
RESULTS
Among the 102 surviving extremely preterm infants, 54 (53%) had hyperglycemia. The hyperglycemia group had lower DQ (81.0 ± 19.3 vs. 91.1 ± 15.3, P < 0.01) and decreased normal DQ rate (37% vs. 75%, P < 0.001). In the multiple logistic regression models, hyperglycemia was significantly associated with lower normal DQ rates (P = 0.03).
CONCLUSION
Hyperglycemia, defined as a blood glucose level of >15 mmol/L, was independently negatively associated with normal DQ after adjusting for confounders.
目的
探讨高血糖对极早产儿神经发育结局的影响。
研究设计
这项单中心回顾性队列研究纳入了孕周小于28周出生的极早产儿。高血糖定义为血糖水平>15 mmol/L。在矫正年龄18个月时采用京都心理发育量表进行神经发育评估，发育商（DQ）≥85定义为正常。
结果
在102例存活的极早产儿中，54例（53%）有高血糖。高血糖组的DQ较低（81.0±19.3 vs. 91.1±15.3，P<0.01），正常DQ率降低（37% vs. 75%，P<0.001）。在多因素logistic回归模型中，高血糖与较低的正常DQ率显著相关（P=0.03）。
结论
血糖水平>15 mmol/L定义的高血糖在调整混杂因素后与正常DQ独立呈负相关。
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