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紫贻贝来源的缩醛磷脂通过脂质代谢和MAPK信号通路对动脉粥样硬化的影响。

Effects of Mytilus edulis derived plasmalogens against atherosclerosis via lipid metabolism and MAPK signaling pathway.

作者信息

Feng Junli, Zhang Jian, Wang Shitong, Li Zhenwei, Yuan Hong, Yao Haiming, Xue Jing, Zheng Jing, Wu Yeshun, Wang Siwei, Zeng Xixi, Cui Yong, Tang Oushan, Cheng Keyun, Shen Qing

机构信息

Zhejiang Key Laboratory of Food Microbiology and Nutritional Health, Collaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.

Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Affiliated First Hospital of Ningbo University, Ningbo, China.

出版信息

NPJ Sci Food. 2025 Aug 18;9(1):178. doi: 10.1038/s41538-025-00546-0.

DOI:10.1038/s41538-025-00546-0
PMID:40826004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12361481/
Abstract

Mytilus edulis-derived plasmalogens (Pls) are rich in polyunsaturated fatty acids, which are reportedly effective in ameliorating cardiovascular disease. The purpose of this study was to clarify the underlying mechanisms of Pls against atherosclerosis (AS) in ApoE mice induced by a high-fat diet (HFD), through a comprehensive analysis of hepatic metabolomics and aortic transcriptomics data. The results demonstrated a significant reduction in pathological indicators associated with AS following Pls treatment. Furthermore, the abundance of hepatic lipid metabolites, which have either anti-inflammatory or pro-inflammatory effects, was significantly altered among experimental groups. Combined with transcriptomics data, it is suggested that these metabolic changes may inhibit MAPK signaling pathway, subsequently suppressing downstream vascular inflammatory responses and activity of NLRP3 inflammasome in Pls-treated mice. Collectively, this study supports the benefits of Pls as effective dietary bioactive phospholipids in preventing HFD-induced AS and related metabolic disorders, possibly through modulation of the MAPK signaling pathway.

摘要

紫贻贝来源的缩醛磷脂（Pls）富含多不饱和脂肪酸，据报道其对改善心血管疾病有效。本研究的目的是通过对肝脏代谢组学和主动脉转录组学数据的综合分析，阐明Pls对高脂饮食（HFD）诱导的ApoE小鼠动脉粥样硬化（AS）的潜在作用机制。结果表明，Pls治疗后与AS相关的病理指标显著降低。此外，在各实验组中，具有抗炎或促炎作用的肝脏脂质代谢物丰度发生了显著变化。结合转录组学数据，提示这些代谢变化可能抑制丝裂原活化蛋白激酶（MAPK）信号通路，进而抑制Pls处理小鼠的下游血管炎症反应和NLRP3炎性小体活性。总体而言，本研究支持Pls作为有效的膳食生物活性磷脂在预防HFD诱导的AS及相关代谢紊乱方面的益处，可能是通过调节MAPK信号通路实现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/56a52da036f9/41538_2025_546_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/f7c48cc485e4/41538_2025_546_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/a2b81ae46b50/41538_2025_546_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/261a9be94528/41538_2025_546_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/6a0ec2d8b63e/41538_2025_546_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/1895ad1b02ea/41538_2025_546_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/d87e12983361/41538_2025_546_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/56a52da036f9/41538_2025_546_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/f7c48cc485e4/41538_2025_546_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/a2b81ae46b50/41538_2025_546_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/261a9be94528/41538_2025_546_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/6a0ec2d8b63e/41538_2025_546_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/1895ad1b02ea/41538_2025_546_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/d87e12983361/41538_2025_546_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa3/12361481/56a52da036f9/41538_2025_546_Fig7_HTML.jpg

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本文引用的文献

[1]
Plasmalogens Reversed Oxidative Stress and Inflammatory Response Exacerbated by Damage to Cell Membrane Properties in Acute Liver Injury.

J Agric Food Chem. 2024-12-25

[2]
Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis.

Nat Cardiovasc Res. 2024-2-1

[3]
Dietary Eicosapentaenoic Acid Containing Phosphoethanolamine Plasmalogens Remodels the Lipidome of White Adipose Tissue and Suppresses High-Fat Diet Induced Obesity in Mice.

Mol Nutr Food Res. 2023-9

[4]
Atherogenesis in and Mice with a Genetically Resistant Background.

Cells. 2023-4-26

[5]
Transcriptomics integrated with metabolomics reveals the ameliorating effect of mussel-derived plasmalogens on high-fat diet-induced hyperlipidemia in zebrafish.

Food Funct. 2023-4-24

[6]
Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes).

Biomed Pharmacother. 2022-12

[7]
Nuciferine attenuates atherosclerosis by regulating the proliferation and migration of VSMCs through the Calm4/MMP12/AKT pathway in ApoE mice fed with High-Fat-Diet.

Phytomedicine. 2023-1

[8]
Integrated application of transcriptome and metabolomics reveals potential therapeutic targets for the polarization of atherosclerotic macrophages.

Biochim Biophys Acta Mol Basis Dis. 2022-12-1

[9]
MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells.

Int J Mol Sci. 2022-9-17

[10]
New Progress in Early Diagnosis of Atherosclerosis.

Int J Mol Sci. 2022-8-11

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