Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis, Jilin Provincial Cardiovascular Research Institute, Jilin University, Changchun 130033, China.
Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute, Jilin University, Changchun 130033, China.
Int J Mol Sci. 2022 Aug 11;23(16):8939. doi: 10.3390/ijms23168939.
Coronary atherosclerosis is a potentially chronic circulatory condition that endangers human health. The biological cause underpinning cardiovascular disease is coronary atherosclerosis, and acute cardiovascular events can develop due to thrombosis, platelet aggregation, and unstable atherosclerotic plaque rupture. Coronary atherosclerosis is progressive, and three specific changes appear, with fat spots and stripes, atherosclerosis and thin-walled fiber atherosclerosis, and then complex changes in arteries. The progression and severity of cardiovascular disease are correlated with various levels of calcium accumulation in the coronary artery. The therapy and diagnosis of coronary atherosclerosis benefit from the initial assessment of the size and degree of calcification. This article will discuss the new progress in the early diagnosis of coronary atherosclerosis in terms of three aspects: imaging, gene and protein markers, and trace elements. This study intends to present the latest methods for diagnosing patients with early atherosclerosis through a literature review.
冠状动脉粥样硬化是一种潜在的慢性循环系统疾病，危害着人类的健康。心血管疾病的生物学基础是冠状动脉粥样硬化，血栓形成、血小板聚集和不稳定的粥样硬化斑块破裂可导致急性心血管事件。冠状动脉粥样硬化是进行性的，会出现三个特定的变化，即脂肪斑和条纹、粥样硬化和薄壁纤维粥样硬化，然后是动脉的复杂变化。心血管疾病的进展和严重程度与冠状动脉内钙积累的各个水平相关。冠状动脉粥样硬化的治疗和诊断受益于对冠状动脉大小和钙化程度的初步评估。本文将从影像学、基因和蛋白质标志物以及微量元素三个方面讨论冠状动脉粥样硬化早期诊断的新进展。本研究旨在通过文献回顾，为诊断早期动脉粥样硬化患者提供最新的方法。
