Zheng Jiaxue, Zheng Peiqing, Han Yi, Zhang Mingyan, Gu Jianzhong
The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Department of Neurology, The First People's Hospital of Xiaoshan, Hangzhou, Zhejiang Province, China.
Medicine (Baltimore). 2025 Aug 15;104(33):e43962. doi: 10.1097/MD.0000000000043962.
The general population shows a correlation between low-intensity physical activity and increased severity of depressive symptom. However, the nature of the relationship between these factors remains unclear among cancer patients. This study seeks to examine the association between physical activity levels and depression in this population. A total of 1993 participants aged 20 to 79 years were selected from the National Health and Nutrition Examination Survey conducted between 2007 and 2018. Multivariate logistic regression analyses were performed using EmpowerStats and R software (version 3.4.3). Among the 1993 cancer patients, 254 (12.7%) reported experiencing depressive symptoms. After adjusting for potential confounding factors, participants engaging in high-intensity physical activity exhibited a 40% lower rate of depression compared to those engaging in low-intensity exercise (OR = 0.60, 95% CI: 0.45-0.81). Stratified analyses further revealed that, in the fully adjusted model, physical activity significantly influenced the risk of depression across subgroups stratified by age, gender, race, education level, marital status, and smoking status. Physical activity emerges as a significant factor influencing depression risk. Additionally, low-intensity physical activity is associated with an elevated likelihood of depressive symptoms among cancer patients.
普通人群中，低强度体育活动与抑郁症状严重程度增加之间存在关联。然而，在癌症患者中，这些因素之间关系的本质仍不清楚。本研究旨在探讨该人群中体育活动水平与抑郁之间的关联。从2007年至2018年进行的国家健康和营养检查调查中选取了1993名年龄在20至79岁之间的参与者。使用EmpowerStats和R软件（版本3.4.3）进行多因素逻辑回归分析。在1993名癌症患者中，254名（12.7%）报告有抑郁症状。在调整潜在混杂因素后，进行高强度体育活动的参与者与进行低强度运动的参与者相比，抑郁发生率低40%（OR = 0.60，95% CI：0.45 - 0.81）。分层分析进一步显示，在完全调整模型中，体育活动在按年龄、性别、种族、教育水平、婚姻状况和吸烟状况分层的亚组中显著影响抑郁风险。体育活动是影响抑郁风险的一个重要因素。此外，低强度体育活动与癌症患者抑郁症状发生可能性增加有关。
