Tian Emma, Wilson Oliver W A, Wojcik Kaitlyn M, Butera Gisela, Schneider Jacob, Rogers Laura Q, Demark-Wahnefried Wendy, Jayasekera Jinani
Division of Intramural Research at the National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.
Office of Research Services, National Institutes of Health Library, Bethesda, MD, USA.
Qual Life Res. 2025 Jul 2. doi: 10.1007/s11136-025-03992-1.
Breast cancer survivors are at increased risk of poor health-related quality of life (HRQOL). Clinical trials suggest physical activity interventions may improve HRQOL, however, evidence on whether these benefits extend to physical activity in real-world settings is limited. We aimed to evaluate the association between post-diagnosis recreational physical activity and HRQOL among breast cancer survivors in the observational literature and compare findings with clinical trial data.
A systematic review was conducted, searching seven databases for studies published between January 2003 and October 2024. Study characteristics and adjusted analyses of the association between recreational physical activity and HRQOL were extracted. A qualitative synthesis categorized HRQOL outcomes into global, physical, emotional, social, and breast cancer-specific domains. Risk of bias was assessed, and findings from observational studies were compared with those from clinical trials.
The search identified 5831 sources, with 11 studies meeting inclusion criteria. For most domains, studies reported positive associations between aerobic activity and HRQOL. Meeting aerobic activity guidelines was found to have clinically meaningful positive associations with global HRQOL (Five studies), physical HRQOL (Two studies), and breast cancer-specific HRQOL (One study). Fewer studies reported on emotional/social domains of HRQOL or the association between muscle-strengthening activity and HRQOL. Overall, observational findings were consistent with clinical trial findings.
Observational evidence suggests that aerobic activity guideline adherence may be associated with increased global and physical HRQOL. These findings indicate that benefits observed in trials may extend to real-world recreational aerobic activity. Further research is needed on muscle-strengthening activity and activity dosage.
乳腺癌幸存者健康相关生活质量（HRQOL）较差的风险增加。临床试验表明体育活动干预可能改善HRQOL，然而，关于这些益处是否能延伸至现实环境中的体育活动的证据有限。我们旨在评估观察性文献中乳腺癌幸存者诊断后休闲体育活动与HRQOL之间的关联，并将结果与临床试验数据进行比较。
进行了一项系统综述，检索了7个数据库，查找2003年1月至2024年10月发表的研究。提取了研究特征以及休闲体育活动与HRQOL之间关联的校正分析结果。进行了定性综合分析，将HRQOL结果分为总体、身体、情感、社会和乳腺癌特异性领域。评估了偏倚风险，并将观察性研究结果与临床试验结果进行了比较。
检索共识别出5831个来源，其中11项研究符合纳入标准。对于大多数领域，研究报告有氧运动与HRQOL之间存在正相关。发现符合有氧运动指南与总体HRQOL（5项研究）、身体HRQOL（2项研究）和乳腺癌特异性HRQOL（1项研究）之间存在具有临床意义的正相关。较少有研究报告HRQOL的情感/社会领域或肌肉强化活动与HRQOL之间的关联。总体而言，观察性研究结果与临床试验结果一致。
观察性证据表明，遵循有氧运动指南可能与总体和身体HRQOL的提高相关。这些发现表明，在试验中观察到的益处可能延伸至现实中的休闲有氧运动。需要对肌肉强化活动和活动剂量进行进一步研究。
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