Wang Ge, Tang Qisheng, Wang Dan
Beijing University of Chinese Medicine Third Affiliated Hospital, Department of Geriatrics, Beijing, China.
Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China.
J Med Biochem. 2025 Jun 13;44(3):561-567. doi: 10.5937/jomb0-53546.
Coronary heart disease (CHD) is a cardiovascular disease with a high incidence in elderly patients. This article aimed to evaluate the clinical efficacy of puerarin (Pue) as an adjuvant therapy in elderly patients with CHD and the effects of Pue on serum NOD-like receptor protein 3 (NLRP3) inflammasome, C1q/TNF-Related Protein 3 (CTRP3) and lipoprotein-associated phospholipase 2 (Lp-PLA2) levels.
This retrospective cohort study compared two treatment approaches for CHD patients at Beijing University of Chinese Medicine Third Affiliated Hospital. Fifty-nine patients received standard treatment (5% glucose + nitroglycerin), and 59 received a new treatment (5% glucose + Pue injection). Outcomes were assessed using electrocardiograms, laboratory tests, and cardiac function evaluations.
Relative to the controls, the study subjects had a reduction in the number of angina episodes and an increase in exercise tolerance. In addition, the serum NLRP3 inflammasome and Lp-PLA2 distinctly decreased, and the serum CTRP3 distinctly increased in study subjects.
The administration of puerarin as an adjuvant therapy in elderly patients with coronary heart disease demonstrated significant clinical efficacy, as evidenced by reduced angina episodes and improved exercise tolerance; this might be driven through inflammatory and lipid metabolism pathways.
冠心病（CHD）是一种在老年患者中发病率较高的心血管疾病。本文旨在评估葛根素（Pue）作为辅助治疗对老年冠心病患者的临床疗效，以及Pue对血清NOD样受体蛋白3（NLRP3）炎性小体、C1q/TNF相关蛋白3（CTRP3）和脂蛋白相关磷脂酶2（Lp-PLA2）水平的影响。
这项回顾性队列研究比较了北京中医药大学第三附属医院冠心病患者的两种治疗方法。59例患者接受标准治疗（5%葡萄糖+硝酸甘油），59例接受新治疗（5%葡萄糖+Pue注射液）。通过心电图、实验室检查和心功能评估来评估结果。
与对照组相比，研究对象的心绞痛发作次数减少，运动耐量增加。此外，研究对象血清中的NLRP3炎性小体和Lp-PLA2明显降低，血清CTRP3明显升高。
在老年冠心病患者中使用葛根素作为辅助治疗具有显著的临床疗效，表现为心绞痛发作次数减少和运动耐量提高；这可能是通过炎症和脂质代谢途径实现的。
