Ma Jiwen, Li Ka
West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China.
Front Cardiovasc Med. 2023 Jul 7;10:1199433. doi: 10.3389/fcvm.2023.1199433. eCollection 2023.
Inflammation has been linked to the development of coronary heart disease (CHD). The systemic immune inflammation index (SII) is a useful biomarker of systemic inflammation. Our study aimed to explore the correlation between SII and CHD.
We conducted a multivariate logistic regression analysis, smoothing curve fitting, and segmented model comparison on 15,905 participants with a CHD prevalence of 3.31% and a mean age of 46.97 years.
Adjusting for gender, age, and race, we found a negative association between SII and CHD [odds ratio (OR) 0.66; 95% confidence interval (CI) 0.48, 0.90]. There was an inverse trend where increasing SII was associated with decreasing odds of CHD ( for trend = 0.0017). After further adjustment, the association was strengthened, with a similar trend ( for trend = 0.0639). Smoothing curve fitting demonstrated a gender-specific association between SII and CHD.
Our findings suggest that higher SII values may be associated with a higher incidence of CHD, which varies by gender. SII may be a cost-effective and convenient method to detect CHD. Further studies are needed to confirm the causality of these findings in a larger prospective cohort.
炎症与冠心病（CHD）的发生有关。全身免疫炎症指数（SII）是全身炎症的一种有用生物标志物。我们的研究旨在探讨SII与CHD之间的相关性。
我们对15905名参与者进行了多因素逻辑回归分析、平滑曲线拟合和分段模型比较，这些参与者的冠心病患病率为3.31%，平均年龄为46.97岁。
在调整性别、年龄和种族后，我们发现SII与CHD之间存在负相关[比值比（OR）0.66；95%置信区间（CI）0.48，0.90]。存在一种相反的趋势，即SII升高与CHD发病几率降低相关（趋势P = 0.0017）。进一步调整后，这种关联得到加强，且趋势相似（趋势P = 0.0639）。平滑曲线拟合显示SII与CHD之间存在性别特异性关联。
我们的研究结果表明，较高的SII值可能与较高的CHD发病率相关，且因性别而异。SII可能是一种检测CHD的经济有效且便捷的方法。需要进一步的研究在更大的前瞻性队列中证实这些发现的因果关系。
