Schütt Ida Christine, Hansen Gustav Emil, Koch-Pedersen Alexander, Lassen Annmarie, Rosenvinge Flemming Schønning, Backer Mogensen Christian, Skjøt-Arkil Helene, Wulff Madsen Lone, Johansen Isik Somuncu
Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
Department of Emergency Medicine, Odense University Hospital, Odense, Denmark.
Ann Med. 2025 Dec;57(1):2546059. doi: 10.1080/07853890.2025.2546059. Epub 2025 Aug 19.
Urinary tract infection (UTI) is a common Emergency Department (ED) diagnosis and cause of hospitalization. This study aimed to assess the incidence of UTI-related referrals and admissions in the Region of Southern Denmark and describe patient demographics, clinical and laboratory findings, readmission rates and mortality.
This retrospective cohort study included all referrals to five EDs in the Region of Southern Denmark from January 1, 2016, to March 19, 2018. Patients aged ≥18 years, with a UTI discharge diagnosis were included.
A total of 3,754 individual UTI patients were identified, corresponding to an incidence of 17.6 per 10,000 person-years and an admission rate of 10.8 per 10,000 person-years. Admitted patients were older (median age: 77 years), had more comorbidities, higher CRP and leukocyte levels ( < .001). was the most frequent pathogen in both urine (66.6%) and blood cultures (53.6%). Admission was associated with male sex (OR 1.32), age 6080 years (OR 3.07), ≥81 (OR 3.60), Charlson Comorbidity Index (CCI) ≥3 (OR 1.34), qSOFA = 1 (OR 1.56), and initiation of antibiotic treatment (OR 4.08). Thirty-day mortality was 7.4%, with age ≥81 (OR 3.86), CCI ≥3 (OR 2.73), and qSOFA = 3 (OR 5.49) as significant risk factors. Among patients who were not admitted at the initial contact, 5.1% required hospitalization within 30 days.
UTIs are a common cause of hospitalization and represent a substantial healthcare burden in Denmark. Older age, male sex, comorbidities, and severe clinical presentations were key predictors of admission and mortality.
尿路感染（UTI）是急诊科常见的诊断疾病及住院原因。本研究旨在评估丹麦南部地区UTI相关转诊和住院的发生率，并描述患者的人口统计学特征、临床和实验室检查结果、再入院率及死亡率。
这项回顾性队列研究纳入了2016年1月1日至2018年3月19日期间转诊至丹麦南部地区五家急诊科的所有患者。纳入年龄≥18岁、出院诊断为UTI的患者。
共识别出3754例UTI患者，发病率为每10000人年17.6例，住院率为每10000人年10.8例。住院患者年龄较大（中位年龄：77岁），合并症更多，CRP和白细胞水平更高（P<0.001）。大肠埃希菌是尿液（66.6%）和血培养（53.6%）中最常见的病原体。住院与男性（OR 1.32）、年龄60 - 80岁（OR 3.07）、≥81岁（OR 3.60）、Charlson合并症指数（CCI）≥3（OR 1.34）、快速序贯器官衰竭评估（qSOFA）=1（OR 1.56）以及开始抗生素治疗（OR 4.08）相关。30天死亡率为7.4%，年龄≥81岁（OR 3.86）、CCI≥3（OR 2.73）和qSOFA = 3（OR 5.49）是显著的危险因素。在初次就诊时未住院的患者中，5.1%在30天内需要住院治疗。
UTI是住院的常见原因，在丹麦代表着相当大的医疗负担。年龄较大、男性、合并症和严重的临床表现是住院和死亡的关键预测因素。
