Suppr超能文献

[线状汗孔角化症中出现的多发性鳞状细胞癌]

[Multiple squamous cell carcinomas arising in linear porokeratosis].

作者信息

Busch Dorothee A, Berking Carola, Schliep Stefan, Erfurt-Berge Cornelia

机构信息

Hautklinik, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Deutschland.

Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CC ER-EMN), 91054, Erlangen, Deutschland.

出版信息

Dermatologie (Heidelb). 2025 Aug 19. doi: 10.1007/s00105-025-05565-2.

Abstract

This case report discusses a 58-year-old patient with linear porokeratosis who subsequently developed cutaneous squamous cell carcinoma. Porokeratosis is a rare keratinisation disorder which carries a risk of malignant transformation. The patient initially presented with recurrent erosions and ulcerations. After initial reluctance of the patient to seek medical help, biopsies confirmed squamous cell carcinoma in several lesions. These were successfully excised and the patient opted for secondary wound healing. Due to its potential for malignancy, porokeratosis often requires diligent monitoring. It typically features hyperkeratotic lesions that can progress over time. Although there are various treatment options for porokeratosis, long-term efficacy is limited. This case emphasises the importance of early biopsy in chronic, nonhealing wounds, as well as the need for patient education and regular follow-up to effectively manage the risk of malignancy.

摘要

本病例报告讨论了一名58岁的线性汗孔角化症患者,该患者随后发展为皮肤鳞状细胞癌。汗孔角化症是一种罕见的角化障碍疾病,存在恶变风险。患者最初表现为反复出现的糜烂和溃疡。在患者最初不愿寻求医疗帮助后,活检证实多个病灶存在鳞状细胞癌。这些病灶被成功切除,患者选择二期伤口愈合。由于汗孔角化症有恶变的可能,通常需要密切监测。其典型特征是角化过度性皮损,可随时间进展。虽然汗孔角化症有多种治疗选择,但长期疗效有限。本病例强调了对慢性不愈合伤口进行早期活检的重要性,以及对患者进行教育和定期随访以有效管理恶变风险的必要性。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验