Sasson M, Krain A D
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Dermatol Surg. 1996 Apr;22(4):339-42. doi: 10.1111/j.1524-4725.1996.tb00327.x.
Porokeratosis is a disorder of epidermal keratinization manifested clinically by a raised border and histologically by a cornoid lamella. While cutaneous malignancy has been reported to arise in porokeratosis, the risk remains unknown. In the past it has been associated with a history of radiation therapy.
The purpose of this study is to estimate the frequency of cutaneous malignancy arising in porokeratosis and define those patients who are at highest risk.
All cases in the English language literature in the last 30 years were reviewed.
Twenty-one (7.5%) of 281 cases reported revealed a malignancy arising within porokeratosis. Large lesions, those of long-standing duration, and the linear type were at greatest risk. Radiation therapy was an infrequently identified risk factor.
Porokeratosis is a premalignant condition, with certain groups of patients at greatest risk for malignant transformation.
汗孔角化症是一种表皮角化异常疾病，临床特征为边界隆起，组织学特征为鸡眼样板层。虽然已有报道称汗孔角化症可发生皮肤恶性肿瘤，但其风险仍不明确。过去，它与放射治疗史有关。
本研究旨在评估汗孔角化症中发生皮肤恶性肿瘤的频率，并确定风险最高的患者群体。
回顾了过去30年英文文献中的所有病例。
281例报告病例中有21例（7.5%）显示在汗孔角化症内发生了恶性肿瘤。大的皮损、病程长的皮损以及线状型皮损风险最高。放射治疗是一个较少见的风险因素。
汗孔角化症是一种癌前病变，某些患者群体发生恶性转化的风险最高。
