Atwal O S, Saldanha K A
Acta Anat (Basel). 1985;124(3-4):245-54. doi: 10.1159/000146124.
Glutaraldehyde-perfused lungs of 5 adult male and female goats were prepared for electron microscopy to study the properties of blood monocytes in the alveolar capillaries, with particular reference to intravascular erythrophagocytosis. Ultrastructural evidence is presented that the majority of intravascular monocytes were active in forming large uropods and filipods and were vigorously phagocytic for erythrocytes. Erythrocytes were engulfed intact and subsequently fragmented. The fragments were hemolyzed and eventually converted into ghost erythrocytes and siderosomes. An electron-dense protein coat was consistently seen on the outer surface of the cell membrane of monocytes. Coated pits, endocytosis and some indication of internalization of the surface coat were evident. It is suggested that blood monocytes in the lung undergo a process of maturation to differentiate into active phagocytes as immediate precursors of alveolar macrophages.
制备了5只成年雌雄山羊经戊二醛灌注的肺用于电子显微镜检查，以研究肺泡毛细血管中血液单核细胞的特性，特别是关于血管内红细胞吞噬作用。超微结构证据表明，大多数血管内单核细胞活跃地形成大的尾足和丝状伪足，并强烈吞噬红细胞。红细胞被完整吞噬，随后破碎。碎片被溶血，最终转化为红细胞影和含铁小体。在单核细胞膜的外表面始终可见电子致密的蛋白质外衣。有被小窝、内吞作用以及表面外衣内化的一些迹象明显可见。提示肺中的血液单核细胞经历一个成熟过程，分化为作为肺泡巨噬细胞直接前体的活跃吞噬细胞。
