Wang Yiqian, Wang Xianhao, Yan Yingqi, Zhao Zihui, Yan Ruxu, Zhang Yuming, Liu Meng, Yue Xianfeng, Wu Qingqing, Ma Xin, Jiang Hongchen, Ji Long, Zhao Xuezhen, Sun Min, Qiao Jianhong, Li Dong
School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China; School of Public Health, Jining Medical University, Jining 272067, China.
School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.
Ecotoxicol Environ Saf. 2025 Aug 18;303:118865. doi: 10.1016/j.ecoenv.2025.118865.
Brominated flame retardants (BFRs) represent a group of synthetic chemical compounds that have been ubiquitously incorporated into numerous consumer products. Human exposure to BFRs occurs through multiple routes, posing potential health risks. However, the association between BFR exposure and hyperuricemia and the role of lipid dysregulation remain unexplored. Data from 1171 respondents to the National Health and Nutrition Examination Survey (NHANES) survey cycle of 2003-2004 were used. We investigated the risk of hyperuricemia (HUA) from mixed BFR exposure using weighted quantile sum (WQS), quantile g-computation (Qgcomp), Bayesian kernel machine regression (BKMR), Elastic Net (ENET), and decision tree classifier (DT) models. The models were interpreted using Shapley Additive exPlanations (SHAP). Our results indicate that the weights of BDE-28, BDE-47, and BDE-99 are higher than those of the other BFR congeners analyzed. Total cholesterol (TC) was found to mediate the effects of BDE-28, BDE-47, and BDE-99 on hyperuricemia, with mediation proportions of 10.11 %, 10.10 %, and 9.55 %, respectively. Functional enrichment analyses revealed significant enrichment in lipid and atherosclerosis pathways. According to our findings, exposure to BFRs fosters hyperuricemia, and dysregulated lipid metabolism is a major contributing factor to this relationship.
溴化阻燃剂（BFRs）是一类合成化合物，已被广泛应用于众多消费品中。人类通过多种途径接触BFRs，这带来了潜在的健康风险。然而，BFRs暴露与高尿酸血症之间的关联以及脂质代谢紊乱的作用仍未得到探索。我们使用了2003 - 2004年美国国家健康与营养检查调查（NHANES）周期中1171名受访者的数据。我们使用加权分位数和（WQS）、分位数g计算（Qgcomp）、贝叶斯核机器回归（BKMR）、弹性网络（ENET）和决策树分类器（DT）模型，研究了混合BFRs暴露导致高尿酸血症的风险。使用夏普利值附加解释（SHAP）对模型进行解释。我们的结果表明，BDE - 28、BDE - 47和BDE - 99的权重高于所分析的其他BFR同系物。发现总胆固醇（TC）介导了BDE - 28、BDE - 47和BDE - 99对高尿酸血症的影响，中介比例分别为10.11%、10.10%和9.55%。功能富集分析显示脂质和动脉粥样硬化途径有显著富集。根据我们的研究结果，接触BFRs会引发高尿酸血症，脂质代谢失调是这种关系的主要促成因素。
