Freire Ivna Vidal, Ribeiro Icaro J S, Casotti Cezar Augusto, Andrade Diego, Bezerra Débora Diniz, Teixeira Jules Ramon Brito, Barbosa Ana Angélica Leal, Campos Luciene Cristina Gastalho, Pereira Rafael
Integrative Physiology Research Center, Department of Biological Sciences, State University of Southwestern Bahia, Jequié, Bahia, Brazil.
Graduate Program in Nursing and Health, State University of Southwestern Bahia, Jequié, Bahia, Brazil.
High Blood Press Cardiovasc Prev. 2025 Aug 20. doi: 10.1007/s40292-025-00725-w.
Adequate blood pressure control (BPC) is crucial for preventing hypertension, as well as for mitigating the risks associated with inadequate control among hypertensive older adults. Identifying modifiable factors (i.e., dietary and biochemical patterns, sociodemographic characteristics, and health habits) and non-modifiable factors (i.e., genetic background) is crucial for improving control rates.
This study aimed to analyze the association between Renin-Angiotensin-Aldosterone System gene polymorphisms, sociodemographic characteristics, health and lifestyle habits, and BPC in older adults.
one hundred and forty-three older adults comprised the study population, and were genotyped for angiotensinogen (AGT) [M235T], renin (REN) [G2646A] angiotensin-converting enzyme (ACE) [InDel], angiotensin II type 1 receptor (AT1R) [A1166C] aldosterone synthase (CYP11B2) [C344T] gene polymorphisms. Sociodemographic characteristics, health, and lifestyle habits were recorded using questionnaires, and blood pressure was measured using standard methods. A Poisson multivariate regression was applied.
Our finding indicated that, together, LDL-C, the A allele of the REN gene (G2646A), and genotype II of the ACE gene (InDel) were significantly associated with inadequate BPC in the community-dwelling older adults.
Due to its non-modifiable nature, the genetic background has the potential to identify individuals with a greater risk of illness. The knowledge of the genetic profiles prone to impaired BPC and its interaction with modifiable factors could guide more effective behaviors and/or treatments aiming to mitigate the morbidity and mortality related to poor BPC among hypertensive older adults.
血压得到充分控制对于预防高血压至关重要，对于降低老年高血压患者因控制不佳而产生的风险也很关键。识别可改变因素（即饮食和生化模式、社会人口学特征及健康习惯）和不可改变因素（即遗传背景）对于提高控制率至关重要。
本研究旨在分析肾素 - 血管紧张素 - 醛固酮系统基因多态性、社会人口学特征、健康和生活方式习惯与老年人血压控制之间的关联。
143名老年人组成研究人群，对其进行血管紧张素原（AGT）[M235T]、肾素（REN）[G2646A]、血管紧张素转换酶（ACE）[InDel]、血管紧张素II 1型受体（AT1R）[A1166C]、醛固酮合酶（CYP11B2）[C344T]基因多态性的基因分型。使用问卷记录社会人口学特征、健康和生活方式习惯，并采用标准方法测量血压。应用泊松多元回归分析。
我们的研究结果表明，低密度脂蛋白胆固醇（LDL - C）、REN基因（G2646A）的A等位基因以及ACE基因（InDel）的II型基因型共同与社区居住老年人血压控制不佳显著相关。
由于遗传背景不可改变，其有可能识别出患病风险更高的个体。了解易出现血压控制受损的基因谱及其与可改变因素的相互作用，可为旨在降低老年高血压患者因血压控制不佳导致的发病率和死亡率的更有效行为和/或治疗提供指导。
