Tegnér R, Lindholm B
Acta Med Scand. 1985;218(4):409-16. doi: 10.1111/j.0954-6820.1985.tb08866.x.
Registrations of clinical signs of neuropathy, quantified according to a fixed protocol, and determinations of vibratory perception thresholds and nerve conduction velocities (NCV) were performed in 22 patients treated with hemodialysis (HD) and in 21 patients treated with continuous ambulatory peritoneal dialysis (CAPD). Measurements were made at the start of dialysis and during a follow-up period of about 30 months. Motor NCV decreased in both groups; vibratory thresholds increased markedly in the CAPD patients, but not in the HD patients; and the clinical signs worsened in the HD patients, but not in the CAPD patients. The difference in outcome of the clinical signs during HD and CAPD was not of such a magnitude that one of these dialysis forms should be preferred before the other as regards neuropathy. We conclude that peripheral neuropathy may deteriorate during both HD and CAPD, but in significantly different ways, indicating that several pathogenetic mechanisms are probably involved in uremic neuropathy.
按照固定方案对22例接受血液透析（HD）治疗的患者和21例接受持续性非卧床腹膜透析（CAPD）治疗的患者进行了神经病变临床体征的记录，并测定了振动觉阈值和神经传导速度（NCV）。在透析开始时及约30个月的随访期内进行测量。两组患者的运动神经传导速度均下降；CAPD患者的振动觉阈值显著升高，而HD患者未升高；HD患者的临床体征恶化，而CAPD患者未恶化。HD和CAPD期间临床体征结果的差异并不足以使其中一种透析方式在神经病变方面比另一种更具优势。我们得出结论，HD和CAPD期间周围神经病变均可能恶化，但方式显著不同，这表明尿毒症性神经病变可能涉及多种发病机制。
