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From genomics to clinical practice: opportunities and challenges in addressing physical comorbidity in SMI.

作者信息

Zhang Junfeng, Liu Xiaoling, Zhang Bao, Chen Xiaoyan

机构信息

Department of Rehabilitation, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

Pediatric Department of Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

出版信息

Front Psychiatry. 2025 Aug 4;16:1627629. doi: 10.3389/fpsyt.2025.1627629. eCollection 2025.

DOI:10.3389/fpsyt.2025.1627629
PMID:40831529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12360074/
Abstract
摘要

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本文引用的文献

1
Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK.严重精神疾病患者身体健康状况的遗传易感性与共病之间的关联：对英国两项横断面观察性研究的分析
Lancet Psychiatry. 2025 Jun;12(6):447-456. doi: 10.1016/S2215-0366(25)00123-3. Epub 2025 May 5.
2
Precision medicine in complex diseases-Molecular subgrouping for improved prediction and treatment stratification.复杂疾病的精准医学-分子亚群分组以改善预测和治疗分层。
J Intern Med. 2023 Oct;294(4):378-396. doi: 10.1111/joim.13640. Epub 2023 Apr 24.
3
Improving polygenic prediction in ancestrally diverse populations.提高在祖源多样化人群中的多基因预测能力。
Nat Genet. 2022 May;54(5):573-580. doi: 10.1038/s41588-022-01054-7. Epub 2022 May 5.
4
Comparative genetic architectures of schizophrenia in East Asian and European populations.东亚和欧洲人群精神分裂症的比较遗传结构。
Nat Genet. 2019 Dec;51(12):1670-1678. doi: 10.1038/s41588-019-0512-x. Epub 2019 Nov 18.
5
The "All of Us" Research Program.“All of Us”研究计划。
N Engl J Med. 2019 Aug 15;381(7):668-676. doi: 10.1056/NEJMsr1809937.
6
Analysis of polygenic risk score usage and performance in diverse human populations.多基因风险评分在不同人群中的使用和表现分析。
Nat Commun. 2019 Jul 25;10(1):3328. doi: 10.1038/s41467-019-11112-0.
7
Clinical use of current polygenic risk scores may exacerbate health disparities.现行多基因风险评分的临床应用可能会加剧健康差异。
Nat Genet. 2019 Apr;51(4):584-591. doi: 10.1038/s41588-019-0379-x. Epub 2019 Mar 29.
8
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.全基因组多基因疾病风险评分可识别出与单基因突变风险相当的个体。
Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13.
9
Research capacity. Enabling the genomic revolution in Africa.研究能力。助力非洲的基因组革命。
Science. 2014 Jun 20;344(6190):1346-8. doi: 10.1126/science.1251546.