Yang Yang, Gu Xiaolin, Zhang Enfan, He Jingsong, Cai Zhen
Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310006, People's Republic of China.
Department of Hematology, Putuo People's Hospital, Zhoushan, Zhejiang, 316100, People's Republic of China.
Int J Gen Med. 2025 Aug 12;18:4359-4367. doi: 10.2147/IJGM.S519598. eCollection 2025.
This study aimed to investigate the knowledge, attitude, and practice (KAP) regarding Waldenström's Macroglobulinemia (WM) among patients and their family members, and to compare differences between these two groups.
This cross-sectional survey was conducted in October 27, 2023 to Nov 27, 2023 at a tertiary hospital in Zhejiang Province, targeting WM patients and their family members. Demographic characteristics and KAP scores were collected through self-administered questionnaires.
A total of 220 valid questionnaires were analyzed, with 98 (44.55%) from patients. The overall mean knowledge, attitude, and practice scores were 10.38±4.07 (possible range: 0-16), 15.78±2.34 (possible range: 5-25), and 23.19±3.31 (possible range: 6-30), respectively. Patients had significantly higher knowledge scores than family members (11.13±4.28 vs 9.78±3.79, P = 0.004), while no significant differences were found in attitude (15.78±2.27 vs 15.77±2.40, P = 0.889) or practice scores (23.59±2.94 vs 22.87±3.56, P = 0.134). Correlation analysis revealed a positive correlation between knowledge and attitude (r = 0.1879, P = 0.0052) and practice (r = 0.1670, P = 0.0132). However, the correlation between attitudes and practices was not significant. Structural equation modeling (SEM) results showed no direct effect between knowledge and attitude (P = 0.312) or knowledge and practice (P = 0.067). In contrast, attitude directly and negatively affected practice (β = -0.10, P = 0.036).
WM patients and their family members demonstrated moderate levels of knowledge, attitudes, and practices toward WM. To enhance clinical outcomes, interventions should focus on improving attitudes, given their direct and negative impact on practices.
本研究旨在调查患者及其家庭成员对华氏巨球蛋白血症（WM）的知识、态度和行为（KAP），并比较这两组之间的差异。
这项横断面调查于2023年10月27日至2023年11月27日在浙江省一家三级医院进行，目标人群为WM患者及其家庭成员。通过自填问卷收集人口统计学特征和KAP得分。
共分析了220份有效问卷，其中98份（44.55%）来自患者。知识、态度和行为的总体平均得分分别为10.38±4.07（可能范围：0 - 16）、15.78±2.34（可能范围：5 - 25）和23.19±3.31（可能范围：6 - 30）。患者的知识得分显著高于家庭成员（11.13±4.28对9.78±3.79，P = 0.004），而态度（15.78±2.27对15.77±2.40，P = 0.889）或行为得分（23.59±2.94对22.87±3.56，P = 0.134）无显著差异。相关性分析显示知识与态度（r = 0.1879，P = 0.0052）和行为（r = 0.1670，P = 0.0132）之间呈正相关。然而，态度与行为之间的相关性不显著。结构方程模型（SEM）结果显示知识与态度（P = 0.312）或知识与行为（P = 0.067）之间无直接影响。相比之下，态度直接且负面地影响行为（β = -0.10，P = 0.036）。
WM患者及其家庭成员对WM的知识、态度和行为水平中等。为提高临床结局，鉴于态度对行为有直接负面影响，干预应侧重于改善态度。
