Shen Zi-Yi, Wang Jie, Shen Xiao-Ping, Xv Bao-Qin, Shen Dan-Ping
Department of Anesthesiology, Suzhou Ninth People's Hospital, Suzhou, People's Republic of China.
Int J Gen Med. 2025 Aug 14;18:4457-4467. doi: 10.2147/IJGM.S509276. eCollection 2025.
To compare the effects of intravenous anesthesia with propofol and inhalation anesthesia with sevoflurane on coagulation and immune system function in patients undergoing radical surgery for colon cancer.
The following were compared between the two groups: blood rheology indicators [plasma viscosity (PV), erythrocyte aggregation index (EAI), erythrocyte deformability index (EDI)], coagulation function indicators [prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D), fibrinogen (FIB)], humoral immune function indicators [immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG)], cellular immune function indicators [CD4+, CD8+, natural killer cells (NK)], postoperative recovery, and postoperative complications.
① Blood Rheology Indicators: At 60 minutes after anesthesia induction, PV, EAI, and EDI levels in both groups decreased compared to pre-anesthesia levels (P < 0.05), with no significant differences between the two groups at the same time point (P > 0.05). ② Coagulation Function Indicators: At 1 day postoperatively, D-D and FIB levels increased compared to 1 day preoperatively, with Group A showing less pronounced changes than Group B (P < 0.05). ③ Humoral Immune Function Indicators: In Group A, humoral immune indicators showed no significant changes at 1 day postoperatively compared to 1 day preoperatively (P > 0.05). In Group B, IgM and IgG levels decreased at 1 day postoperatively compared to 1 day preoperatively and were lower than those in Group A at the same time point (P < 0.05). ④ Cellular Immune Function Indicators: At 1 day postoperatively, CD4+, CD8+, and NK cell levels decreased in both groups compared to 1 day preoperatively.
Propofol and sevoflurane have similar effects on perioperative blood rheology in colon cancer patients. However, propofol has a lesser impact on coagulation and immune function compared to sevoflurane, making it more effective in promoting postoperative recovery and reducing the risk of related postoperative complications.
比较丙泊酚静脉麻醉与七氟醚吸入麻醉对结肠癌根治术患者凝血及免疫系统功能的影响。
比较两组患者的血液流变学指标[血浆黏度（PV）、红细胞聚集指数（EAI）、红细胞变形能力指数（EDI）]、凝血功能指标[凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、D-二聚体（D-D）、纤维蛋白原（FIB）]、体液免疫功能指标[免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）]、细胞免疫功能指标[CD4+、CD8+、自然杀伤细胞（NK）]、术后恢复情况及术后并发症。
①血液流变学指标：麻醉诱导后60分钟，两组患者的PV、EAI及EDI水平均较麻醉前降低（P<0.05），同一时间点两组间差异无统计学意义（P>0.05）。②凝血功能指标：术后1天，D-D及FIB水平较术前1天升高，A组变化幅度小于B组（P<0.05）。③体液免疫功能指标：A组术后1天体液免疫指标与术前1天比较差异无统计学意义（P>0.05）。B组术后1天IgM及IgG水平较术前1天降低，且低于同一时间点A组（P<0.05）。④细胞免疫功能指标：术后1天，两组患者的CD4+、CD8+及NK细胞水平均较术前1天降低。
丙泊酚和七氟醚对结肠癌患者围手术期血液流变学的影响相似。然而，与七氟醚相比，丙泊酚对凝血及免疫功能的影响较小，在促进术后恢复及降低相关术后并发症风险方面更具优势。
