Yamakoshi Haruna, Horigome Mihoko, Yamamoto Shotaro, Iwanami Shoya, Iwami Shingo, Tanaka Ryoya, Ishikawa Yuki, Kamikouchi Azusa
Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, Japan.
Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi 464-8602, Japan.
iScience. 2025 Jul 29;28(9):113232. doi: 10.1016/j.isci.2025.113232. eCollection 2025 Sep 19.
Mating status often modulates responses to courtship sounds in animals. The neural mechanisms underlying this modulation, however, have not been well clarified. Here, we show that dopaminergic signals are involved in modulating the responses of auditory sensory neurons in females depending on their mating status. These neurons abundantly express three types of dopamine receptors, with some having direct synaptic connections with dopaminergic neurons. Of these receptors, suppressing the expression of Dop1R2 reduces sound responses of auditory sensory neurons in unmated but not mated females. Moreover, the expression of Dop1R2 in auditory sensory neurons enhances the song response behavior of unmated females, manifested by copulation receptivity when exposed to songs. Our research suggests that dopaminergic modulation via Dop1R2 is involved in mating the state-dependent regulation of auditory sensory processing.
交配状态常常会调节动物对求偶声音的反应。然而，这种调节背后的神经机制尚未得到充分阐明。在这里，我们表明多巴胺能信号参与根据雌性的交配状态调节听觉感觉神经元的反应。这些神经元大量表达三种类型的多巴胺受体，其中一些与多巴胺能神经元有直接的突触连接。在这些受体中，抑制Dop1R2的表达会降低未交配但非已交配雌性的听觉感觉神经元的声音反应。此外，听觉感觉神经元中Dop1R2的表达增强了未交配雌性的鸣叫反应行为，表现为在接触鸣叫时的交配接受性。我们的研究表明，通过Dop1R2的多巴胺能调节参与了交配状态依赖的听觉感觉处理调节。
