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撞到门:一例作为肺动静脉畸形并发症的脑脓肿病例报告。

Bumping Into Doors: A Case Report of Brain Abscess as a Complication of Pulmonary Arteriovenous Malformation.

作者信息

Pilate Sylvain, Van Olmen Daan, Sergant Ilse, Vandereyken Frederik

机构信息

Department of Emergency, AZ Klina, Brasschaat, BEL.

Department of Emergency, Ziekenhuis Geel, Geel, BEL.

出版信息

Cureus. 2025 Jul 19;17(7):e88315. doi: 10.7759/cureus.88315. eCollection 2025 Jul.

Abstract

Cerebral abscess is an infection of the central nervous system that can cause a variety of neurologic signs. The majority of infections are caused by distant haematogenous spread, neurotrauma, surgery, or contiguous infections. Another rare source of a brain abscess is a pulmonary arteriovenous malformation (PAVM). Late diagnosis and neurological complications associated with brain abscesses can cause significant morbidity or even mortality. We present the case of a 75-year-old Caucasian male with complaints of subfebrillitas, headache, and difficulty in estimating distances. A diagnosis of brain abscess was made. The abscess was drained, and ceftriaxone plus metronidazole was initiated. After the cultures were positive for and , the therapy was de-escalated to penicillin G and metronidazole. In search of a focus, a PAVM was identified and subsequently embolised. Brain abscess is a relatively rare condition. The prevalence of PAVMs is also considered uncommon. The majority of cases is linked to hereditary haemorrhagic telangiectasia (HHT), an autosomal dominant hereditary disease, but PAVMs can also occur as a single-standing problem. Neurological events such as cerebral abscess, stroke, or migraine may occur in some cases of PAVMs. To prevent complications, embolisation of every radiographically visible PAVM needs to be considered. Moreover, PAVMs should be considered in the search for the aetiology of a brain abscess when routine investigations fail to detect other causes. The coexistence of HHT in every patient with PAVMs also needs to be considered.

摘要

脑脓肿是一种中枢神经系统感染,可导致多种神经体征。大多数感染是由远处血行播散、神经外伤、手术或邻近感染引起的。脑脓肿的另一个罕见病因是肺动静脉畸形(PAVM)。脑脓肿的晚期诊断和相关神经并发症可导致严重的发病率甚至死亡率。我们报告一例75岁白种男性病例,患者有低热、头痛及距离估算困难等症状。诊断为脑脓肿。脓肿进行了引流,并开始使用头孢曲松加甲硝唑治疗。培养结果显示 和 呈阳性后,治疗方案降级为青霉素G和甲硝唑。为寻找感染源,发现了一处PAVM并随后进行了栓塞。脑脓肿是一种相对罕见的疾病。PAVM的患病率也被认为不常见。大多数病例与遗传性出血性毛细血管扩张症(HHT)有关,这是一种常染色体显性遗传病,但PAVM也可作为单独的问题出现。在某些PAVM病例中可能会发生诸如脑脓肿、中风或偏头痛等神经事件。为预防并发症,需要考虑对每一处影像学可见的PAVM进行栓塞。此外,当常规检查未能发现其他病因时,在寻找脑脓肿病因时应考虑PAVM。还需要考虑每例PAVM患者中HHT的共存情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e6/12360676/b404ae2c5b3c/cureus-0017-00000088315-i01.jpg

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