Diumenjo M S, Lisanti M, Vallés R, Rivero I
Allergol Immunopathol (Madr). 1985 Jul-Aug;13(4):323-6.
Clinical experience suggests that allergic signs and symptoms are more frequently observed in patients with systemic lupus erythematosus than in the general population. The aim of this paper was to evaluate the frequency of allergic clinical manifestations in systemic lupus erythematosus (SLE) by anamnesis. Sixty three SLE patients, 51 cases of other autoimmune diseases and 133 healthy individuals, were included in the study. The protocol was taken from Goldman's paper on the same subject (4): urticaria, rhinitis, pharyngitis, conjunctivitis, asthma, eczema and allergy to foods, drugs and insect stings were recorded. The results disclosed that 76% of SLE cases, 37% of those with other autoimmune diseases and versus healthy controls had had one or more of those clinical manifestations throughout their lives (SLE versus other autoimmune diseases and versus healthy controls; p: less than 0,0005; other autoimmune diseases versus healthy controls; p: not significant). The frequency of each of the following-urticaria, pharyngitis, conjunctivitis and food allergy was statistically increased in SLE. Furthermore, patients with SLE had the highest incidence of different types of clinical manifestations per individual. Allergic manifestations in SLE are thought to express: a higher level of hypersensitivity to exogenous antigens, or disease activity through cytotropic autoantibodies or through anaphylactoid products of complement activation.
临床经验表明，系统性红斑狼疮患者比普通人群更频繁地出现过敏体征和症状。本文旨在通过问诊评估系统性红斑狼疮（SLE）患者过敏临床表现的发生率。本研究纳入了63例SLE患者、51例其他自身免疫性疾病患者和133名健康个体。研究方案取自戈德曼关于同一主题的论文（4）：记录荨麻疹、鼻炎、咽炎、结膜炎、哮喘、湿疹以及对食物、药物和昆虫叮咬的过敏情况。结果显示，76%的SLE患者、37%的其他自身免疫性疾病患者以及健康对照者在其一生中曾出现过一种或多种上述临床表现（SLE与其他自身免疫性疾病以及与健康对照者相比；p：小于0.0005；其他自身免疫性疾病与健康对照者相比；p：无显著性差异）。SLE患者中荨麻疹、咽炎、结膜炎和食物过敏的发生率在统计学上有所增加。此外，SLE患者个体出现不同类型临床表现的发生率最高。SLE中的过敏表现被认为表明：对外源抗原的超敏反应水平较高，或通过嗜细胞性自身抗体或补体激活的类过敏产物表现出疾病活动。
