Gotuzzo E, Bocanegra T S, Alarcón G S, Carrillo C, Espinoza L R
Allergol Immunopathol (Madr). 1985 Sep-Oct;13(5):417-24.
Humoral immune responses were evaluated in a group of patients with acute brucellosis due to Brucella melitensis biotype I. Levels of immunoglobulins, C3 and C4, and the presence of antinuclear antibodies, rheumatoid factor and circulating immune complexes were sequentially studied in all brucellosis patients during the acute phase of the disease and following specific therapy. Elevated levels of all immunoglobulin classes, IgG, IgM and IgA and C3, C4, were found in the majority of patients. Antinuclear antibodies, rheumatoid factor and circulating immune complexes were found in circulation, particularly during the active stages. These findings provide support for the participation of the humoral immune system in the pathogenesis of human brucellosis.
对一组因羊种布鲁氏菌生物I型感染所致急性布鲁氏菌病患者的体液免疫反应进行了评估。在所有布鲁氏菌病患者疾病急性期及特异性治疗后，依次研究了免疫球蛋白、C3和C4水平，以及抗核抗体、类风湿因子和循环免疫复合物的存在情况。大多数患者的所有免疫球蛋白类别（IgG、IgM和IgA）以及C3、C4水平均升高。在循环中发现了抗核抗体、类风湿因子和循环免疫复合物，尤其是在疾病活动期。这些发现为体液免疫系统参与人类布鲁氏菌病发病机制提供了支持。
