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大肠杆菌素基因在发育中的婴儿肠道微生物群中高度普遍。

Colibactin genes are highly prevalent in the developing infant gut microbiome.

作者信息

Levy Shira, McCauley Kathryn E, Strength Rachel, Robbins Emily S, Chen Qing, Namasivyam Sivaranjani, Maxwell George, Hourigan Suchitra K

出版信息

medRxiv. 2025 Aug 13:2025.08.12.25333511. doi: 10.1101/2025.08.12.25333511.

DOI:10.1101/2025.08.12.25333511
PMID:40832390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12363750/
Abstract

Early-life exposure to colibactin-producing + gut bacteria is hypothesized to imprint mutations on the colorectal epithelium, increasing the risk of colorectal cancer later in life. We demonstrate an extremely high prevalence of bacteria (>50% of infants) during the first two years of life, suggesting carriage is likely normal during early-life microbiome development. Further research is needed into the conditions in which carriage can lead to mutagenesis.

摘要

据推测，生命早期接触产生大肠杆菌素的肠道细菌会在结肠直肠上皮细胞上留下突变印记，增加日后患结直肠癌的风险。我们证明，在生命的头两年中，这类细菌的携带率极高（超过50%的婴儿），这表明在生命早期微生物群发育过程中，携带此类细菌可能是正常现象。对于携带此类细菌会导致诱变的条件，还需要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656b/12363750/c0dfd68768e9/nihpp-2025.08.12.25333511v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656b/12363750/7550f9a04ca5/nihpp-2025.08.12.25333511v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656b/12363750/c0dfd68768e9/nihpp-2025.08.12.25333511v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656b/12363750/7550f9a04ca5/nihpp-2025.08.12.25333511v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/656b/12363750/c0dfd68768e9/nihpp-2025.08.12.25333511v1-f0002.jpg

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本文引用的文献

1
Delivery mode impacts gut bacteriophage colonization during infancy.分娩方式影响婴儿期肠道噬菌体的定植。
Gut Microbes Rep. 2025;2(1). doi: 10.1080/29933935.2025.2464631. Epub 2025 Mar 14.
2
Effects of antibiotic exposure on risks of colorectal tumors: a systematic review and meta-analysis.抗生素暴露对结直肠肿瘤风险的影响：一项系统评价和荟萃分析。
J Transl Med. 2025 Jun 18;23(1):682. doi: 10.1186/s12967-025-06727-5.
3
Geographic and age variations in mutational processes in colorectal cancer.结直肠癌突变过程中的地理和年龄差异。
Nature. 2025 Apr 23. doi: 10.1038/s41586-025-09025-8.
4
Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli.结直肠癌和泌尿系统癌症发病率的地理差异与人群暴露于产大肠杆菌素的大肠杆菌有关。
Lancet Microbe. 2025 May;6(5):101015. doi: 10.1016/j.lanmic.2024.101015. Epub 2024 Dec 4.
5
Vaginal delivery provides skin colonization resistance from environmental microbes in the NICU.阴道分娩可增强新生儿重症监护病房（NICU）中新生儿对环境微生物的皮肤定植抵抗力。
Clin Transl Med. 2023 Dec;13(12):e1506. doi: 10.1002/ctm2.1506.
6
Contribution of pks E. coli mutations to colorectal carcinogenesis.pks E. coli 突变在结直肠癌变中的作用。
Nat Commun. 2023 Nov 29;14(1):7827. doi: 10.1038/s41467-023-43329-5.
7
Shotgun metagenomic sequencing on skin microbiome indicates dysbiosis exists prior to the onset of atopic dermatitis.皮肤微生物组的 shotgun 宏基因组测序表明，特应性皮炎发病前就存在微生物失调。
Allergy. 2023 Oct;78(10):2724-2731. doi: 10.1111/all.15806. Epub 2023 Jul 8.
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