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To modify or not to modify-That is still the question for some mRNA applications.

作者信息

Soler Sofía, Maser Katharina, Zillinger Thomas, Bartok Eva

机构信息

Institute of Experimental Haematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany.

Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.

出版信息

Mol Ther Nucleic Acids. 2025 Aug 11;36(3):102655. doi: 10.1016/j.omtn.2025.102655. eCollection 2025 Sep 9.

DOI:10.1016/j.omtn.2025.102655
PMID:40832630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12359151/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef45/12359151/506bb051705e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef45/12359151/506bb051705e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef45/12359151/506bb051705e/gr1.jpg

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本文引用的文献

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The impact of nucleoside base modification in mRNA vaccine is influenced by the chemistry of its lipid nanoparticle delivery system.信使核糖核酸（mRNA）疫苗中核苷酸碱基修饰的影响受其脂质纳米颗粒递送系统化学性质的影响。
Mol Ther Nucleic Acids. 2023 May 8;32:794-806. doi: 10.1016/j.omtn.2023.05.004. eCollection 2023 Jun 13.
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Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine.
先天免疫和适应性免疫对辉瑞-生物科技 BNT162b2 疫苗的作用机制。
Nat Immunol. 2022 Apr;23(4):543-555. doi: 10.1038/s41590-022-01163-9. Epub 2022 Mar 14.
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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses.脂质纳米颗粒通过诱导强烈的滤泡辅助性 T 细胞和体液反应来提高 mRNA 和蛋白亚单位疫苗的效力。
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