• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

分子量为64,000的淋巴细胞胞质多肽（LCP1）与酯酶D之间紧密连锁的证据。

Evidence for the close linkage between lymphocyte cytosol polypeptide with molecular weight of 64,000 (LCP1) and esterase D.

作者信息

Kondo I, Hamaguchi H

出版信息

Am J Hum Genet. 1985 Nov;37(6):1106-11.

PMID:4083280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1684732/
Abstract

The genetic linkage of the loci for lymphocyte cytosol polypeptide with molecular weight of 64,000 (LCP1) and esterase (ESD) were examined by two-dimensional gel electrophoresis using blood from four informative families. No recombinants were observed in the four families totaling 17 children, giving a summed lod score of 4.221 at recombination fraction 0. This result indicates that the gene for LCP1 is closely linked to the ESD locus, which is assigned to the chromosomal region 13q14.11. This finding also suggests that the LCP1 locus is linked to the retinoblastoma gene, which is assigned to the same chromosomal region and closely linked to the ESD locus.

摘要

利用来自四个信息丰富家庭的血液，通过二维凝胶电泳检测了分子量为64,000的淋巴细胞胞质多肽（LCP1）基因座与酯酶（ESD）的遗传连锁关系。在总共17名儿童的四个家庭中未观察到重组体，在重组率为0时，累积lod分数为4.221。这一结果表明，LCP1基因与ESD基因座紧密连锁，ESD基因座定位于染色体区域13q14.11。这一发现还表明，LCP1基因座与视网膜母细胞瘤基因连锁，该基因定位于同一染色体区域且与ESD基因座紧密连锁。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8a/1684732/a55a5edd1438/ajhg00162-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8a/1684732/a55a5edd1438/ajhg00162-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8a/1684732/a55a5edd1438/ajhg00162-0062-a.jpg

相似文献

1
Evidence for the close linkage between lymphocyte cytosol polypeptide with molecular weight of 64,000 (LCP1) and esterase D.分子量为64,000的淋巴细胞胞质多肽（LCP1）与酯酶D之间紧密连锁的证据。
Am J Hum Genet. 1985 Nov;37(6):1106-11.
2
A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13.一名患有视网膜母细胞瘤且存在13号染色体长臂缺失的患者的病例报告：人类13号染色体上一个新基因（LCP1基因）的定位
Hum Genet. 1985;71(3):263-6. doi: 10.1007/BF00284588.
3
Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: VI. Identification of esterase D in the two-dimensional gel electrophoresis pattern of cellular proteins.通过二维凝胶电泳对人淋巴细胞蛋白质进行遗传分析：VI. 在细胞蛋白质二维凝胶电泳图谱中鉴定酯酶D
Hum Genet. 1984;66(2-3):248-51. doi: 10.1007/BF00286611.
4
Close linkage of the Wilson's disease locus to D13S12 in the chromosomal region 13q21 and not to ESD in 13q14.威尔逊氏病基因座与染色体区域13q21中的D13S12紧密连锁，而不与13q14中的酯酶D（ESD）紧密连锁。
Hum Genet. 1990 Oct;85(5):560-2. doi: 10.1007/BF00194238.
5
Accuracy of detection of the retinoblastoma gene by esterase D linkage.通过酯酶D连锁检测视网膜母细胞瘤基因的准确性
Arch Ophthalmol. 1985 Sep;103(9):1329-31. doi: 10.1001/archopht.1985.01050090081036.
6
Re-evaluation of the sublocalization of esterase D and its relation to the retinoblastoma locus by in situ hybridization.
Cytogenet Cell Genet. 1987;44(2-3):153-7. doi: 10.1159/000132361.
7
Esterase D assay in Brazilian retinoblastoma families.巴西视网膜母细胞瘤家族中的酯酶D检测
Am J Med Genet. 1989 Nov;34(3):391-6. doi: 10.1002/ajmg.1320340314.
8
Esterase D and retinoblastoma gene loci are tightly linked to Wilson's disease in Chinese pedigrees from Taiwan.酯酶D和视网膜母细胞瘤基因位点与来自台湾的中国家系中的威尔逊氏病紧密连锁。
Hum Genet. 1991 Aug;87(4):465-8. doi: 10.1007/BF00197170.
9
Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis. VII. Genetic polymorphism of cytosol polypeptide with molecular weight of 38,000.
Hum Genet. 1985;70(4):328-32. doi: 10.1007/BF00295371.
10
An assessment of the usefulness of electrophoretic variants of esterase-D in the antenatal diagnosis of retinoblastoma in the United Kingdom.英国酯酶-D电泳变异体在视网膜母细胞瘤产前诊断中的效用评估。
Br J Cancer. 1987 Jun;55(6):661-4. doi: 10.1038/bjc.1987.135.

引用本文的文献

1
Error detected in published lod scores.已发表的对数优势比分数中检测到错误。
Am J Hum Genet. 1986 Oct;39(4):544.
2
A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13.一名患有视网膜母细胞瘤且存在13号染色体长臂缺失的患者的病例报告：人类13号染色体上一个新基因（LCP1基因）的定位
Hum Genet. 1985;71(3):263-6. doi: 10.1007/BF00284588.
3
Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis. VIII. Genetic polymorphism of cytosol polypeptide with molecular weight of 20,000.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Sequential tests for the detection of linkage.用于检测连锁的序贯检验。
Am J Hum Genet. 1955 Sep;7(3):277-318.
3
Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14.人类酯酶D和视网膜母细胞瘤基因在13号染色体14区带的区域定位。
用双向凝胶电泳法对人淋巴细胞蛋白质进行遗传分析。VIII. 分子量为20000的胞质溶胶多肽的遗传多态性
Hum Genet. 1986 Apr;72(4):303-6. doi: 10.1007/BF00290953.
4
Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.丝束蛋白的分子克隆与特性分析，一种在转化的人成纤维细胞中表达的人白细胞蛋白。
Mol Cell Biol. 1988 Nov;8(11):4659-68. doi: 10.1128/mcb.8.11.4659-4668.1988.
Science. 1980 May 30;208(4447):1042-4. doi: 10.1126/science.7375916.
4
Retinoblastoma-del(13q14): report of two patients, one with a trisomic sib due to maternal insertion. Gene-dosage effect for esterase D.视网膜母细胞瘤 - del(13q14)：两例患者报告，其中一例患者的母亲存在插入现象，其同胞为三体。酯酶D的基因剂量效应。
Hum Genet. 1981;59(3):211-4. doi: 10.1007/BF00283666.
5
Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 4. Genetic polymorphism of cytosol 100k polypeptide.通过二维凝胶电泳对人淋巴细胞蛋白质进行遗传分析：4. 胞质溶胶100k多肽的遗传多态性。
Hum Genet. 1982;62(2):148-51. doi: 10.1007/BF00282304.
6
Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 3. Frequent occurrence of genetic variants in some abundant polypeptides of PHA-stimulated peripheral blood lymphocytes.通过二维凝胶电泳对人淋巴细胞蛋白质进行遗传分析：3. 促有丝分裂原激活的外周血淋巴细胞某些丰富多肽中遗传变异的频繁出现。
Hum Genet. 1982;62(2):142-7. doi: 10.1007/BF00282303.
7
Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 2. Genetic polymorphism of lymphocyte cytosol 64K polypeptide.通过二维凝胶电泳对人淋巴细胞蛋白质进行遗传分析：2. 淋巴细胞胞质溶胶64K多肽的遗传多态性。
Hum Genet. 1982;60(2):176-80. doi: 10.1007/BF00569708.
8
Retinoblastoma in a boy with a de novo mutation of a 13/18 translocation: the assumption that the retinoblastoma locus is at 13q141, particularly at the distal portion of it.一名患有13/18易位新发突变男孩的视网膜母细胞瘤：视网膜母细胞瘤基因座位于13q141，尤其是其远端部分的假设。
Hum Genet. 1982;60(2):193-5. doi: 10.1007/BF00569711.
9
Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma.13号染色体上基因的体细胞失活在视网膜母细胞瘤中是常见现象。
Nature. 1983;304(5925):451-3. doi: 10.1038/304451a0.
10
Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D.通过与酯酶D的连锁分析，将遗传性视网膜母细胞瘤基因定位于人类第13号染色体。
Science. 1983 Feb 25;219(4587):971-3. doi: 10.1126/science.6823558.