Hamaguchi H, Yamada M, Shibasaki M, Kondo I
Hum Genet. 1982;62(2):148-51. doi: 10.1007/BF00282304.
We describe a genetic polymorphism of a human cellular polypeptide with mol. wt. 100,000, detected in peripheral blood lymphocytes by high resolution two-dimensional electrophoresis. Three different electrophoretic types (1-1, 2-1, and 2-2) of the polypeptide have been identified. Family and population studies indicate that the three phenotypes of the polypeptide are determined by two common alleles at a single autosomal locus. The polypeptide occurs in the cytosol and is one of the abundant polypeptides of B-lymphoblastoid cells, T-lymphoblastoid cells, fibroblasts, and HeLa cells. The data indicate that the cytosol polypeptide with mol. wt. 100,000 shows a genetic polymorphism determined by a new autosomal locus. It is proposed that the polypeptide and its locus be temporarily designated cytosol 100k polypeptide (C100k polypeptide) and C100P, respectively. In a Japanese population, the gene frequencies of C100P1 and C100P2 were 0.907 and 0.093, respectively.
我们描述了一种分子量为100,000的人细胞多肽的遗传多态性，通过高分辨率二维电泳在外周血淋巴细胞中检测到。已鉴定出该多肽的三种不同电泳类型（1-1、2-1和2-2）。家系和群体研究表明，该多肽的三种表型由常染色体上单一基因座的两个常见等位基因决定。该多肽存在于胞质溶胶中，是B淋巴母细胞、T淋巴母细胞、成纤维细胞和HeLa细胞中丰富的多肽之一。数据表明，分子量为100,000的胞质溶胶多肽显示出由一个新的常染色体基因座决定的遗传多态性。建议将该多肽及其基因座分别暂时命名为胞质溶胶100k多肽（C100k多肽）和C100P。在日本人群中，C100P1和C100P2的基因频率分别为0.907和0.093。
